Academic Career and Research Areas
Professor Busch (b. 1966) conducts research into infection immunology with the goal of identifying therapeutically useful defense mechanisms. His work centers on antigen-specific T cells and the development of new technologies to make immune cells usable for diagnostic and cell therapy applications.
After studying medicine in Mainz and Freiburg (1993) and completing his doctorate (1993), Professor Busch commenced his clinical infectiological training in pediatrics (Würzburg, 1993-1996). He subsequently went to Yale University supported by a DFG scholarship (1996-1999). Having qualified as a lecturer in 2003, Professor Busch completed his residency in medical microbiology and epidemiology of infection (2005) at TUM. He heads the focus group “Clinical Cell Processing and Purification” at the TUM Institute for Anvanced study and co-initiated two sucessful start-ups (STAGE cell therapeutics GmbH and T Cell Factory B.V.). He serves on the board of the German Center for Infection Research and acts as its deputy spokesperson, and is member of the Leopoldina German National Academy of Sciences. Since 2009, he has held the position of director of TUM’s Institute for Medical Microbiology, Immunology and Hygiene since 2009.
- Science Day Award, Helmholtz Zentrum München (2008)
- Wilhelm Vaillant Award (2003)
- Robert Koch Post-doctoral Award (2002)
- Sir Hans Krebs Prize, Society of Friends of the Hannover Medical School (2002)
- Gerhard Hess Research Award, DFG (2000)
Key Publications (all publications)
Graef P, VR Buchholz, C Stemberger, M Flossdorf, L Henkel, M Schiemann, I Drexler, T Hofer, SR Riddell, DH Busch: "Serial transfer of single-cell-derived immunocompetence reveals stemness of CD8(+) central memory T cells". Immunity. 2014; 41: 116-26.Abstract
Nauerth M, B Weissbrich, R Knall, T Franz, G Dossinger, J Bet, PJ Paszkiewicz, L Pfeifer, M Bunse, W Uckert, R Holtappels, D Gillert-Marien, M Neuenhahn, A Krackhardt, MJ Reddehase, SR Riddell, DH Busch: "TCR-ligand koff rate correlates with the protective capacity of antigen-specific CD8+ T cells for adoptive transfer". Sci Transl Med. 2013; 5: 192ra87.Abstract
Buchholz VR, Flossdorf M, Hensel I, Kretschmer L, Weissbrich B, Graf P, Verschoor A, Schiemann M, Hofer T, Busch DH: "Disparate individual fates compose robust CD8+ T cell immunity". Science. 2013; 340: 630-5.Abstract
Verschoor A, Neuenhahn M, Navarini AA, Graef P, Plaumann A, Seidlmeier A, Nieswandt B, Massberg S, Zinkernagel RM, Hengartner H, Busch DH: "A platelet-mediated system for shuttling blood-borne bacteria to CD8alpha(+) dendritic cells depends on glycoprotein GPIb and complement C3". Nat Immunol. 2011; 12: 1194-201.Abstract
Knabel M, Franz TJ, Schiemann M, Wulf A, Villmow B, Schmidt B, Bernhard H, Wagner H, Busch DH: “Reversible MHC multimer staining for functional isolation of T cell populations and effective adoptive transfer”. Nature Medicine. 2002; 8: 631-637.Abstract