Academic Career and Research Areas
Prof. Feige (*1979) pursues an interdisciplinary approach to address fundamental questions in cellular protein biochemistry: how do cells control that the proteins they produce are correctly structured? How is it ensured that defective proteins are recognized and degraded instead of having potentially harmful effects on the organism? Which molecules and mechanisms underlie this molecular quality control? For these questions, the laboratory of Prof. Feige focusses on medically relevant proteins of the human immune and nervous system so that insights into the principles of cellular quality control can ultimately be translated into new biomedical and biotechnological applications.
Professor Feige studied biochemistry at ETH Zurich and TUM, from where he received his doctorate in 2009. After working as a postdoctoral research fellow in the laboratory of Professor Linda Hendershot at St. Jude Children’s Research Hospital in Memphis, TN, USA, he was appointed as a Rudolf Mößbauer Tenure Track Assistant Professor of Cellular Protein Biochemistry at the TUM Department of Chemistry in 2014.
- Fellow of the Daimler and Benz Foundation (2016)
- Rainer Rudolph Foundation, Rainer Rudolph Award (2012)
- Fellow of the German National Academy of Sciences Leopoldina (2011)
- Management Engineers Presidential Award, Management Engineers and TUM (2011)
- Hans Fischer Award, Hans Fischer Society (2010)
Key Publications (all publications)
Reitberger S, Haimerl P, Aschenbrenner I, Esser-von Bieren J, Feige MJ: "Assembly-induced folding regulates interleukin 12 biogenesis and secretion". J Biol Chem. 2017; 292(19): 8073-8081.Abstract
Behnke J, Mann M, Scruggs FL, Feige MJ, Hendershot LM: "Members of the Hsp70 family recognize distinct types of sequences to execute ER quality control". Mol Cell. 2016; 63(5): 739-752.Abstract
Feige MJ, Gräwert MA, Marcinowski M, Hennig J, Behnke J, Ausländer D, Herold EM, Peschek J, Castro CD, Flajnik M, Hendershot LM, Sattler M, Groll M, Buchner J: “The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins“. PNAS. 2014; 111(22): 8155-60.Abstract
Feige MJ, Hendershot LM: “Quality control of integral membrane proteins by assembly-dependent membrane integration”. Mol Cell. 2013; 51(3): 297-309.Abstract
Feige MJ, Groscurth S, Marcinowski M, Shimizu Y, Kessler H, Hendershot LM, Buchner J: “An unfolded CH1 domain controls the assembly and secretion of IgG antibodies”. Mol Cell. 2009; 34(5): 569-579.Abstract