Persönlicher Status und Werkzeuge

Prof. Dr. Michael Groll

Chair

Biochemistry

Department

Chemistry

Contact Details

Business card at TUMonline

Academic Career and Research Areas

Prof. Dr. Groll (b. 1971) conducts research in the field of biochemistry, investigating the structure and function of biological multimeric protein complexes. He is also interested in the basic structure of protein-protein and protein-ligand interactions. Another area of research is the medical relevance of synthetic and natural molecules in terms of their interaction with proteins.

After studying chemistry at TUM, Prof. Groll did his doctorate in biophysics under Prof. Dr. R. Huber at the Max Planck Institute in Martinsried, Munich. In 2002, he was invited to work under Prof. Dr. Finley at the Harvard Medical School. From 2003 to 2006, he organized an independent junior research group at Munich’s Ludwig Maximilian University. He completed his qualification as a lecturer in biochemistry in 2004 externally under the supervision of Prof. Dr. P. Kloetzel at the Charité in Berlin. He was a preclinical junior professor there from 2006 to 2007. Since 2007, he has held the position of full professor of biochemistry at TUM.

Awards

  • Peter und Traudl Engelhorn Biotechnologie-Preis (2001)

Key Publications

Gräwert T, Span I, Eisenreich W, Rohdich F, Eppinger J, Bacher A and Groll M: "Probing the reaction mechanism of IspH protein by X-ray structure analysis". Proc. Natl. Acad. Sci. USA. 2010; 107 (3): 1077-81.

Schreiner P, Chen X, Husnjak K, Randles L, Zhang N, Elsasser S, Finley D, Dikic I, Walters K and Groll M: "Ubiquitin docking at the proteasome via a novel PH domain interaction". Nature. 2008; 453 (7194): 548-552.

Groll M, Schellenberg B, Bachmann AS, Archer CR, Huber R, Powell TK, Lindow S, Kaiser M and Dudler R: "A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism". Nature. 2008; 452 (7188): 755-8.

Groll M, Bajorek M, Kohler A, Moroder L, Rubin DM, Huber R, Glickman M and Finley D: "A gated channel into the proteasome core particle". Nature Struct. Biol. 2000; 7: 1062-1067.

Groll M, Ditzel L, Löwe J, Stock D, Bochtler M, Bartunik HD and Huber R: "Structure of the 20S proteasome from yeast at 2.4Ả resolution". Nature. 1997; 386: 463-471.