Academic Career and Research Areas
Prof. Hrabĕ de Angelis’ areas of research include genetics, diabetes, phenotyping and data mining. He studied biology at Philipps University in Marburg and completed his PhD on the influence of growth factors on early embryonic development in 1994. During his time as a postdoctoral researcher (1994 – 1997) at the Jackson Laboratory in Bar Harbor (USA), he examined the Delta/Notch signaling pathway and somitogenesis in mouse models.
Since 2000, he has been director of the Institute of Experimental Genetics at the Helmholtz Zentrum München (German Research Center for Environmental Health). In 2003, he was appointed to the Chair of Experimental Genetics at TUM. He is also the director of the European research consortium "INFRAFRONTIER". In 2001, he founded the German Mouse Clinic (GMC) for the systemic analysis of mouse models for human disease. His published research articles, have been cited over 25 000 times. He directs national and international research projects and is co-founder and board member of the German Center for Diabetes Research.
- Dr. vet. h.c. awarded by LMU Munich (2018)
- Member of the National Academy of Science „Leopoldina“ (2018)
- Dr. med h.c. awarded by University Tübingen (2016) and University Dresden (2018)
- „Paula und Richard von Hertwig price for interdisciplinary research (2010 + 2003)
- “Incarico di Ricerca”, Italien (2001)
Key Publications (all publications)
Rozman J, [...], Hrabě de Angelis M: “Identification of genetic elements in metabolism by high-througput mouse phenotyping”. Nature Communications. 2018; 9: 288Abstract
Huypens P, Sass S, Wu M, Dyckhoff D, Tschöp M, Theis F, Marschall S, Hrabě de Angelis M, Beckers J: “Epigenetic germline inheritance of diet-induced obesity and insulin resistance”. Nature Genetics. 2016; 48(5): 497-499.Abstract
Hrabě de Angelis M, Nicholson G, Selloum M, White JK, [...], Brown SDM: “Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics”. Nature Genetics. 2015; 47(9): 969-978.Abstract
Neschen S, Scheerer M, Seelig A, Huypens P, Schultheiss J, Wu M, Rathkolb B, Suhre K, Wolf E, Beckers J, Hrabě de Angelis M: “Metformin supports the antidiabetic effect of a sodium glucose cotransporter 2 (SGLT2) inhibitor by suppressing endogenous glucose production in diabetic mice”. Diabetes. 2014; 64(1): 284-290.Abstract
Gailus-Durner V, Fuchs H, [...], Hrabě de Angelis M: “Introducing the German Mouse Clinic: open access platform for standardized phenotyping”. Nature Methods. 2005; 2(6): 403-404.Abstract