Academic Career and Research Areas
Prof. Klingenspor (b. 1961) researches the mechanisms of metabolic regulation with the aim of identifying how nutrition affects the body’s energy balance, i.e. the balance between energy intake and energy expenditure. His work centers on examining regulation of the efficiency of energy conversion in mitochondria as the powerhouses of eukaryotic cells.
After studying biology (1994), Prof. Klingenspor did his doctorate at Philipp University of Marburg. Thanks to a research grant from the German Research Foundation (DFG) (1995/96), he went to work in the laboratory of Prof. Karen Reue at West Los Angeles VA Medical Center (USA). He returned to Marburg to complete his lecturer qualification (2001) in zoology and animal physiology. He became deputy head of that university’s Department of Animal Physiology (2004). In 2007, he accepted TUM’s offer of the Chair of Molecular Nutritional Medicine. Prof. Klingenspor is an appointed expert in various German and international research organizations. He is the co-editor of the Journal of Comparative Physiology B, Obesity Facts, Physiological Reviews und Scientific Reports.
- Deputy speaker of the DFG Research Training Group RTG1482 (2012-2017)
- Dean of Study Division for Nutrition Sciences, TUM (since 2012)
- Else Kröner-Fresenius-Stiftung Endowment Professorship (2007)
- Associate Editor of American Journal of Physiology – Regulatory, Integrative and Comparative Physiology, Bethesda, USA. (2006-2012)
- Young Investigator Award of the Philipps-University Marburg (2001)
Key Publications (all publications)
Li Y, Schnabl K, Gabler SM, Willershäuser M, Reber J, Karlas A, Laurila S, Lahesmaa M, U Din M, Bast-Habersbrunner A, Virtanen KA, Fromme T, Bolze F, O’Farrell LS, Alsina-Fernandez J, Coskun T, Ntziachristos V, Nuutila P, Klingenspor M: "Secretin-activated brown fat mediates prandial thermogenesis to induce satiation". Cell. 2018; 175(6): 1561-1574.Abstract
Bolze F, Bast A, Mocek S, Morath V, Yuan D, Rink N, Schlapschy M, Zimmermann A, Heikenwalder M, Skerra A, Klingenspor M: "Treatment of diet-induced lipodystrophic C57BL/6J mice with long-acting PASylated leptin normalises insulin sensitivity and hepatic steatosis by promoting lipid utilisation". Diabetologia. 2016; 59(9): 2005-2012.Abstract
Kübeck R, Bonet-Ripoll C, Hoffmann C, Walker A, Müller VM, Schüppel VL, Lagkouvardos I, Scholz B, Engel KH, Daniel H, Schmitt-Kopplin P, Haller D, Clavel T, Klingenspor M: "Dietary fat and gut microbiota interactions determine diet-induced obesity in mice". Molecular Metabolism. 2016; 5(12): 1162-1174.Abstract
Schöttl T, Kappler L, Fromme T, Klingenspor M: "Limited OXPHOS capacity in white adipocytes is a hallmark of obesity in laboratory mice irrespective of the glucose tolerance status". Molecular Metabolism. 2015; 4(9): 631-642.Abstract
Li Y, Fromme T, Schweizer S, Schöttl T, Klingenspor M: "Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes". EMBO Reports. 2014; 15(10): 1069-1076.Abstract