Prof. Dr. Stefan Lichtenthaler
Academic Career and Research Areas
Professor Lichtenthaler (b. 1968) conducts research on the molecular basis of neurodegenerative diseases such as Alzheimer’s disease. The goal is to gain a better understanding of these common forms of dementia, to develop new diagnostic and therapeutic approaches and to be able to better predict the possible side effects of medication. This research is carried out using biochemical and proteomic methods such as quantitative mass spectrometry.
Professor Lichtenthaler studied chemistry at the Universities of Karlsruhe, Montpellier (France) and Heidelberg. He earned his doctoral degree at ZMBH, Heidelberg University’s Center for Molecular Biology. After working as a postdoctoral researcher at Harvard University (USA) he led a junior research group at LMU Munich where he also acquired his postdoctoral teaching qualification (habilitation) for his work in the field of biochemistry. In 2009 he was appointed head of department at DZNE, the newly established German Center for Neurodegenerative Diseases. Since 2012 he has been full professor of proteomics at TUM and DZNE.
- Alzheimer Research Award of the Hans and Ilse Breuer Foundation (2014)
- Emmy-Noether grant recipient (1999-2001)
- Dr. Sophie Bernthsen Prize recipient (1994)
Kuhn PH, Koroniak K, Hogl S, Colombo A, Zeitschel U, Willem M, Volbracht C, Schepers S, Imhof A, Hoffmeister A, Haass C, Roßner S, Bräse S, Lichtenthaler SF: „Secretome Protein Enrichment with Click Sugars Identifies Physiological Substrates of the Alzheimer Protease BACE1 in Primary Neurons“. EMBO J. 2012; 31(14): 3157-3168.Abstract
Lichtenthaler SF: „Cell Biology: Sheddase Gets Guidance“. Science. 2012; 335(6065): 179-180.Abstract
Kuhn PH, Wang H, Dislich B, Colombo A, Zeitschel U, Ellwart JW, Kremmer E, Roßner S, Lichtenthaler SF: „ADAM10 is the Physiologically Relevant, Constitutive Alpha-Secretase of the Amyloid Precursor Protein in Primary Neurons“. EMBO J. 2012; 29(17): 3020-3032.Abstract
Mitterreiter S, Page RM, Kamp F, Hopson J, Winkler E, Ha HR, Hamid R, Herms J, Mayer TU, Nelson DJ, Steiner H, Stahl T, Zeitschel U, Rossner S, Haass C, Lichtenthaler SF: „Bepridil and Amiodarone Simultaneously Target the Alzheimer’s Disease beta- and gamma-Secretase via Distinct Mechanisms“. J Neurosci. 2010; 30(26): 8974-8983.Abstract
Friedmann E, Hauben E, Maylandt K, Schleeger S, Vreugde S, Lichtenthaler SF, Kuhn PH, Stauffer D, Rovelli G, Martoglio B: „SPPL2a and SPPL2b promote intramembrane proteolysis of TNFalpha in activated dendritic cells to trigger IL-12 production“. Nat Cell Biol. 2006; 8: 843-848.Abstract