Academic Career and Research Areas
Proteins are the chief effectors of biological functions. As a result, their timely and accurate synthesis is essential for cellular homeostasis. Prof. Nedialkova (*1983) investigates through the lens of systems biology how the mechanisms of protein synthesis and folding work together to maintain homeostasis in distinct environments, and how this synergy is perturbed in disease.
Prof. Nedialkova studied biotechnology at the University of Perugia (Italy) from 2001 to 2004 and received her doctorate in molecular virology from Leiden University (The Netherlands) in 2010. She later worked as a postdoc at the Max Planck Institute for Molecular Biomedicine in Münster, with a long-term fellowship from the European Molecular Biology Organization. Since 2017, she leads the Max Planck Research Group “Mechanisms of Protein Biogenesis” at the MPI of Biochemistry in Martinsried. That same year, she was appointed as a Tenure-Track Professor for Biochemistry of Gene Expression through the MaxPlanck@TUM program.
Key Publications (all publications)
Jungfleisch J, Nedialkova DD, Dotu I, Sloan KE, Bruening L, Raineri E, Bohnsack M, Leidel SA, Diez J: "A novel and conserved translational control mechanism involving RNA structures within coding sequences". Genome Research. 2017; 27(1): 95-106.Abstract
Nedialkova DD, Leidel SA: "Optimization of codon translation rates via tRNA modifications maintains proteome integrity". Cell. 2015; 161(7): 1606-1618.Abstract
Laguesse S, Creppe C, Nedialkova DD, Prévot P-P, Borgs L, Huysseune S, Franco B, Duysens G, Krusy N, Lee G, Thelen N, Thiry M, Close P, Chariot A, Malgrange B, Leidel SA, Godin JD, Nguyen L: "A dynamic unfolded protein response contributes to the control of cortical neurogenesis". Developmental Cell. 2015; 35(5): 553-567.Abstract
Nedialkova DD, Gorbalenya AE, Snijder EJ: "Arterivirus nsp1 modulates the accumulation of minus-strand templates to control the relative abundance of viral mRNAs". PLoS Pathogens. 2010; 6(2): e1000772.Abstract
Nedialkova DD, Ulferts R, van den Born E, Lauber C, Gorbalenya AE, Ziebuhr J, Snijder EJ: "Biochemical characterization of arterivirus nonstructural protein 11 reveals the nidovirus-wide conservation of a replicative endoribonuclease". Journal of Virology. 2009; 83(11): 5671–5682.Abstract