Academic Career and Research Areas
Professor Pichlmair (b. 1978) researches the interaction between viral pathogens and their host organisms. Viruses activate innate immune mechanisms which play a key role in the body’s defense against pathogens. Professor Pichlmair primarily uses mass spectrometry and similar “large scale” techniques in order to conduct system analyses. The hypotheses drawn from such analyses serve to identify signaling cascades and mechanisms involved in the antiviral immune response.
Professor Pichlmair studied at the University of Veterinary Medicine Vienna. He completed his doctoral work (Dr. med. Vet., 2004) at the Institute of Virology, Albert Ludwig University of Freiburg, under Professor Otto Haller. In 2008 he obtained a PhD from the London Research Institute, Cancer Research UK, where he was supervised by Professor Caetano Reis e Sousa. From 2008 to 2011, he worked as a post-doctoral researcher at the Center for Molecular Medicine, Austria Academy of Sciences under Professor Giulio Superti-Furga. He then went on to set up his own laboratory at the Max Planck Institute of Biochemistry, Munich, as part of the Max Planck Free Floater Program (2011-2017). Professor Pichlmair took up a professorship at TUM in July 2017.
- Loeffler Frosch Prize, Society for Virology (GfV) (2013)
- Ponteocorvo Prize for best PhD thesis, Cancer Research UK (2008)
- Golden Badge of Honor, University of Veterinary Medicine Vienna (2006)
Key Publications (all publications)
Holze C, Michaudel C, Mackowiak C, Haas DA, Benda C, Hubel P, Pennemann FL, Schnepf D, Wettmarshausen J, Braun M, Leung DW, Amarasinghe GK, Perocchi F, Staeheli P, Ryffel B, Pichlmair A: "Oxeiptosis, a ROS-induced caspase-independent apoptosis-like cell-death pathway". Nat Immunol. 2018; 19(2): 130-140.Abstract
Scaturro P, Stukalov A, Haas DA, Cortese M, Draganova K, Płaszczyca A, Bartenschlager R, Götz M, Pichlmair A: "An orthogonal proteomic survey uncovers novel Zika virus host factors". Nature. 2018; 561(7722): 253-257.Abstract
Pichlmair A, Kandasamy K, Alvisi G, Mulhern O, Sacco R, Habjan M, Binder M, Stefanovic A, Eberle CA, Goncalves A, Bürckstümmer T, Müller A, Fauster A, Holze A, Lindsten K, Goodbourn S, Kochs G, Weber F, Bartenschlager R, Bowie AG, Bennett KL, Colinge J, Superti-Furga G: "Viral immune modulators perturb the human molecular network by common and unique strategies". Nature. 2012; 487(7408): 486-490.Abstract
Pichlmair A, Lassnig C, Eberle CA, Górna MW, Baumann CL, Burkard TR, Bürckstümmer T, Stefanovic A, Krieger S, Bennett KL, Rülicke T, Weber F, Colinge J, Müller M, Superti-Furga G: "IFIT1 is an antiviral protein that recognizes 5’-triphosphate RNA". Nat Immunol. 2011; 12(7): 624-630.Abstract
Pichlmair A, Schulz O, Tan CP, Näslund TI, Liljeström P, Weber F, Reis e Sousa C: "RIG-I-mediated antiviral responses to single stranded RNA bearing 5’ phosphates". Science. 2006; 314(5801): 997-1001.Abstract