Prof. Dr. Matthias J. Feige
Academic Career and Research Areas
How do cells control that the proteins they produce possess the correct structure? How is it ensured that defective proteins are recognized and degraded instead of having potentially harmful effects on the organism? Which molecules and mechanisms underlie this molecular quality control? Professor M. Feige (b. 1979) addresses these questions with a particular focus on both secretory and membrane proteins. These protein classes play an important role in the interaction of cells with their environment, e.g. in the human immune system. In Professor Feige’s lab for Cellular Protein Biochemistry a particular emphasis is laid on proteins of direct medical relevance so that insights into the principles of cellular quality control might ultimately be translated into new biomedical and biotechnological applications.
Professor Feige studied biochemistry at ETH Zurich and TUM, from where he received his doctorate in 2009. After working as a postdoctoral research fellow in the laboratory of Professor Linda Hendershot at St. Jude Children’s Research Hospital in Memphis, TN, USA, he was appointed as a Rudolf Mößbauer Tenure Track Assistant Professor of Cellular Protein Biochemistry at TUM Department of Chemistry in 2014.
- Rainer Rudolph Award (2012)
- Fellow of the German Academy of Sciences, Leopoldina (2011-2014)
- Management Engineers Presidential Award (2011)
- Hans Fischer Award (2010)
- Fellow of the German National Merit Foundation (Studienstiftung des deutschen Volkes) (2003-2009)
Key Publications (alle Publikationen)
Feige MJ, Gräwert MA, Marcinowski M, Hennig J, Behnke J, Ausländer D, Herold EM, Peschek J, Castro CD, Flajnik M, Hendershot LM, Sattler M, Groll M, Buchner J: “The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins“. PNAS. 2014; 111(22): 8155-60.Abstract
Feige MJ, Hendershot LM: “Quality control of integral membrane proteins by assembly-dependent membrane integration”. Mol Cell. 2013; 51(3): 297-309.Abstract
Marcinowski M, Höller M, Feige MJ, Baerend D, Lamb DC, Buchner J: “Substrate discrimination of the chaperone BiP by autonomous and cochaperone-regulated conformational transitions”. NSMB. 2011; 18(2): 150-158.Abstract
Feige MJ, Groscurth S, Marcinowski M, Shimizu Y, Kessler H, Hendershot LM, Buchner J: “An unfolded CH1 domain controls the assembly and secretion of IgG antibodies”. Mol Cell. 2009; 34(5): 569-579.Abstract
Feige MJ, Groscurth S, Marcinowski M, Yew ZT, Truffault V, Paci E, Kessler H, Buchner J: “The structure of a folding intermediate provides insight into differences in immunoglobulin amyloidogenicity”. PNAS. 2008; 105(36): 13373-13378.Abstract