Prof. Dr. Tobias Alexander Marius Gulder

Assistant Professor

Biosystems Chemistry



Contact Details

Business card at TUMonline

Academic Career and Research Areas

Professor Tobias Gulder (b. 1978) is interested in the structure, biosynthesis and synthesis of bacterial natural products. This includes the elucidation of new biosynthetic transformations and their application to the biocatalytic synthesis of natural products as well as the manipulation of biosynthetic pathways to generate new molecular structures. This is achieved by combining organic synthesis, chemical analytics, biochemical, and biomolecular methods.
Professor Gulder studied Chemistry in Würzburg (1998-2004). In 2008 he was awarded a doctorate (with distinction) from the same university for his work on marine natural products under the supervision of Professor Bringmann. During a postdoctoral research fellowship working with Professor Moore at the Scripps Institution of Oceanography (La Jolla, USA, 2008-2010) he worked on the biosynthesis of marine natural products. As of 2011 Professor Gulder carried out independent research at the University of Bonn. In February 2014 he accepted a W2 faculty appointment as professor of biosystems chemistry at TUM.


  • Thieme Chemistry Journals Award (2013)
  • Emmy Noether Fellowship (2011)
  • Liebig Fellowship (2011)
  • DECHEMA PhD Award for work in the field of Natural Product Chemistry (2009)
  • PhD Award of the Faculty of Chemistry and Pharmacy, University of Würzburg (2008)

Key Publications

Antosch J, Schaefers F, Gulder TAM: „Heterologe Expression des bakteriellen Ikarugamycin-iPKS/NRPS-Systems in E. coli“. Angew. Chem. 2014; in press.

Kampa A, Gagunashvili AN, Gulder TAM, Daolio C, Godejohann M, Miao V, Piel J, Andresson ÒS: “Metagenomic Natural Product Discovery in Lichen Provides Evidence for a Family of Biosynthetic Pathways in Diverse Symbioses”. Proc. Natl. Acad. Sci. USA. 2013; published online, Doi: 10.1073/pnas.13058671102013.


Gulder TAM, Hong H, Correa J, Egereva E, Wiese J, Imhoff JF, Gross H: “Isolation, Structure Elucidation and Total Synthesis of Lajollamide A from the Marine Fungus Asteromyces cruciatus”. Mar. Drugs. 2012; 10(12): 2912-2935.


Gulder TAM, Moore BS: “The Salinosporamide Natural Product Family: Potent 20S Proteasome Inhibitors as Potential Cancer Chemotherapeutics”. Angew. Chem. 2010, 122(49): 9534-9556.


Bringmann G, Noll T, Gulder TAM, Grüne M, Dreyer M, Wilde C, Pankewitz F, Hilker M, Payne GD, Jones AL, Goodfellow M, Fiedler HP, Moore BS: “Different Polyketide Folding Modes Converge to an Identical Molecular Architecture. Nature Chem. Biol. 2006; 2: 429-433.