TUM – Technical University of Munich Menü

Prof. Dr. Matthias Rief


Molecular Biophysics



Academic Career and Research Areas

The focus of Professor Rief’s research is molecular biophysics.
After studying physics at TUM (1995) and receiving a doctoral degree at Ludwig Maximilian University in Munich, Professor Rief worked as a post-doc at Stanford University (USA) from 1998 to 2000. Prior to his appointment to the Chair of Molecular Biophysics at TUM (2003), he was a visiting professor (2000-2001) and later an associate professor at Ludwig Maximilian University.


  • Nanowissenschaftspreis (2003)
  • Heinz Maier-Leibnitz-Preis der Deutschen Forschungsgemeinschaft (2000)
  • Jahrespreis der Deutschen Gesellschaft für Biophysik (1999)
  • Promotionspreis der Ludwig-Maximilians-Universität München (1999)

Key Publications

Gebhardt JC, Bornschlogl T, Rief M: "Full distance-resolved folding". Proc. Natl. Acad. Sci. 2010; 107: 2013-2018.


Junker  JP, F Ziegler, M Rief: "Ligand-dependent equilibrium fluctuations of single calmodulin molecules". Science. 2009; 323: 633-637.


Bertz M, Wilmanns M, Rief M: "The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk". Proc. Natl. Acad. Sci. 2009; 106: 13307-133310.


Dietz H, Berkemeier F, Bertz M, Rief M: "Anisotropic deformation response of single protein molecules". Proc. Natl. Acad. Sci. 2006; 103:12724-12728.


Rief M, Gautel M, Oesterhelt F, Fernandez JM, Gaub HE: "Reversible unfolding of individual titin immunoglobulin domains by AFM". Science. 1997; 276: 1109-1112.