Prof. Dr. Jürgen Ruland
Academic Career and Research Areas
Prof. Ruland (*1966) concentrates his research on signaling processes in the immune system, both normal and when deregulated due to disease. With his research group, he is investigating how normal immune cells recognize pathogens and by what mechanisms this recognition initiates immune defense. The group is also examining how pathologically deregulated signals in blood cells lead to malignant transformation and thus to the development of cancer. The aim is to provide a basis for therapeutic manipulation of the immune system.
Prof. Ruland studied medicine in Giessen and Pittsburgh and graduated in pharmacology. After medical and research work at TUM, Freiburg University, the Ontario Cancer Institute and the AMGEN Research Institute at the University of Toronto he became head of a junior research group of German Cancer Aid at TUM in 2003. He completed his postdoctoral studies in medicine in 2005 and has been professor of molecular immunology at TUM from 2010 to 2012. Since 2012 he is professor of clinical chemistry. He is member of the National Academy of Sciences Leopoldina, the Bavarian Academy of Sciences and Humanities and the German Cancer Aid committee for promoting young medical professionals and scientists.
- ERC Advanced Grant (2013)
- Paul-Martini-Preis (2010)
- Wilhelm-Warner-Preis für Krebsforschung (2010)
- Wissenschaftspreis der Arbeitsgemeinschaft für Internistische Onkologie (2007)
- Artur-Pappenheim-Preis der Deutschen Gesellschaft für Hämatologie und Onkologie (2006)
Key Publications (all publications)
Roth S, Rottach A, Lotz-Havla AS, Laux V, Muschaweckh A, Gersting SW, Muntau AC, Hopfner KP, Jin L, Vanness K, Petrini JH, Drexler I, Leonhardt H, Ruland J: "Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1beta production". Nat Immunol. 2014; 15: 538-545.Abstract
Poeck H, Bscheider M, Gross O, Finger K, Hannesschläger K, Schlee M, Rebsamen M, Rothenfusser S, Akira S, Endres S, Peschel C, Hartmann G, Hornung V, Ruland J: „Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production”. Nat Immunol. 2010; 11: 63-69.Abstract
Gross O, Poeck H, Bscheider M, Dostert C, Hannesschläger N, Endres S, Hartmann G, Tardivel A, Schweighoffer E, Tybulewicz V, Mocsai A, Tschopp J, Ruland J: „Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence”. Nature. 2009; 459: 433-6.Abstract
Gross O, Gewies A, Finger K, Schäfer M, Sparwasser T, Peschel C, Förster I, Ruland J: „Card9 controlls a non-TLR signalling pathway for innate anti-fungal immunity”. Nature. 2006; 442: 651-6.Abstract
Ruland J, Duncan GS, Elia A, del Barco Barrantes I, Nguyen L, Plyte S, Millar DG, Bouchard D, Wakeham A, Ohashi PS, Mak TW: „Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure”. Cell. 2001; 104: 33-42.Abstract