Prof. Dr. Michael Sattler
Academic Career and Research Areas
The research of Prof. Sattler (b. 1965) focuses on the development and application of biomolecular nuclear magnetic resonance spectroscopy (NMR). His aim is to describe the structure, dynamics and molecular interactions of biological macromolecules (proteins, RNAs with each other and with small molecules and drug-like compounds). This should lead to a better understanding of the basic molecular principles of fundamental biological processes and disease mechanisms.
After studying chemistry and completing his doctorate (1995) at J.W. Goethe University in Frankfurt, Prof. Sattler went to Chicago to do research under Dr. Stephen W. Fesik (Abbott Laboratories). In 1997, he was group leader at the European Laboratory for Molecular Biology (EMBL) in Heidelberg. Since 2007, he has been full professor at TUM’s chemistry department in Garching. Prof. Sattler is also Director of the Institute of Structural Biology at Helmholtz Zentrum München and Director of the Bavarian NMR Center.
Key Publications (all publications)
Mackereth CD, Madl T, Bonnal S, Simon B, Zanier K, Gasch A, Rybin V, Valcarcel J, Sattler M: “Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF”. Nature. 2011; 475(7356): 408-411.Abstract
Corsini L, Bonnal S, Basquin J, Hothorn M, Scheffzek K, Valcarcel J, Sattler M: “U2AF Homology Motif interactions are required for alternative splicing regulation by SPF45”. Nat. Struct. Mol. Biol. 2007; 14: 620-9.Abstract
Lingel A, Simon B, Izaurralde E, and Sattler M: “Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain”. Nature. 2003; 426: 465-9.Abstract
Liu Z, Luyten I, Bottomley MJ, Messias AC, Houngninou-Molango S, Sprangers R, Zanier K, Krämer A, Sattler M: “Structural basis for recognition of the intron branch site RNA by splicing factor 1”. Science. 2001; 294: 1098-102.Abstract
Sattler M, Liang H, Nettesheim D, Meadows RP, Harlan JE, Eberstadt M, Yoon HS, Shuker SB, Chang BS, Minn AJ, Thompson CB, Fesik SW: "Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis". Science. 1997; 275: 983-6.Abstract