Persönlicher Status und Werkzeuge

Prof. Dr. Barbara Treutlein

Assistant Professor

Single Cell Genomics

Department

Contact Details

Business card at TUMonline

Academic Career and Research Areas

In her interdisciplinary research, Prof. Treutlein (*1982) integrates the fields of single-cell genomics, developmental biology and stem cell biology. She develops and applies microfluidics-based methods to measure the transcriptome of single cells. Using these methods, Prof. Treutlein tries to understand the genetic foundations of human organ development, how this process can be mimicked under controlled conditions in vitro, and what goes wrong when mutations in the genome lead to developmental disorders.
Prof. Treutlein (*1982) studied chemistry at the Universities of Tübingen and Mainz and at UC Berkeley (2001-2007). From 2007 to 2012, she performed her doctoral research in single-molecule biophysics with Jens Michaelis at LMU Munich, followed by a Postdoc in the field of single-cell genomics with Stephen Quake at Stanford University from 2012 to 2014. Since 2015, she has been a Max Planck Research group leader at the MPI-EVA in Leipzig and the MPI-CBG in Dresden. In 2016, Barbara Treutlein was appointed as a tenure-track assistant professor at TUM.

    Awards

    • Friedmund Neumann Prize (2016)
    • Ph.D. Prize, Dr. Klaus Römer Foundation Munich (2012)
    • Doctoral fellowship, Boehringer Ingelheim Fonds (2008)
    • Boehringer Ingelheim Prize, Boehringer Ingelheim Foundation (2008)
    • Scholarship, German Academic Scholarship Foundation (2002)

    Key Publications

    Treutlein B*, Lee QY*, Camp JG, Mall M, Koh W, Shariati SAM, Sim S, Neff NF, Skotheim JM, Wernig M, Quake S: „Dissecting direct reprogramming from fibroblast to neuron using single-cell RNA-seq“. Nature. 2016; 534: 391-395.

    Abstract

    Gokce O*, Stanley GM*, Treutlein B*, Neff NF, Camp JG, Malenka RC, Rothwell PE, Fuccillo MV, Sudhof TC, Quake SR: „Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq“. Cell Reports. 2016; 16(4): 1126-1137.

    Abstract

    Camp JG*, Badsha F*, Florio M, Kanton S, Gerber T, Wilsch-Bräuninger M, Lewitus E, Sykes A, Hevers W, Lancaster M, Knoblich JA, Lachmann R, Pääbo S, Huttner WB, Treutlein B: „Human cerebral organoids recapitulate gene expression programs of fetal neocortex development“. PNAS. 2015; 112(51): 15672-15677.

    Abstract

    Treutlein B*, Brownfield DG*, Wu AR, Neff NF, Mantalas GL, Espinoza FH, Desai TJ, Krasnow MA and Quake SR: „Reconstructing lineage hierarchies of the distal lung epithelium using single cell RNA-seq“. Nature. 2014; 509: 371-375.

    Abstract

    Treutlein B*, Gokce O*, Sudhof TC, Quake SR: „Cartography of Neurexins mapped by single-molecule long-read mRNA sequencing“. PNAS. 2014; 111(13): 1291-99.

    Abstract