Dr. Jan P. Böttcher
Academic Career and Research Areas
Dr. Jan Böttcher (*1984) investigates the mechanisms that control immunity to cancer within tumors and their surrounding microenvironment. The group focuses on the intercellular communication among local cellular networks, including tumor cells, stromal cells and tumor-infiltrating immune cells. One focus is the regulation of ILCs, dendritic cells and T cells in cancer. The long-term aim of Dr. Jan Böttcher’s research is the discovery of targets suitable for the development of cancer immunotherapies.
Dr. Jan Böttcher studied Molecular Biomedicine at the University of Bonn. From 2008-2013, he conducted his PhD in Immunology at the Institute of Molecular Medicine in Bonn, where he studied the development of T cell immunity and memory. After receiving his PhD (summa cum laude) in 2013, Dr. Jan Böttcher joined Caetano Reis e Sousa’s group at the Francis Crick Institute in London to conduct his postdoctoral research on anti-cancer immunity by dendritic cells and innate lymphocytes in solid tumors. Dr. Jan Böttcher was awarded funding from the Elite Network of Bavaria to form his independent Junior Research Group at the Institute of Molecular Immunology.
Awards
- BIAL Award in Biomedicine 2019 (2020, as Co-Author)
- Fritz-and-Ursula Melchers Prize, German Society for Immunology (2018)
- International Junior Research Group, Elite Network of Bavaria (since 2018)
- Marie Sklodowska-Curie Intra-European Fellowship (2015-2017)
- Postgraduate Scholarship LIMES – Chemical Biology (2008-2011)
Key Publications
Böttcher, J.P., Bonavita, E., Chakravarty, P., Blees, H., Cabeza-Cabrerizo, M., Sammicheli, S., Rogers, N.C., Sahai, E., Zelenay, S., Reis e Sousa, C., 2018. NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control. Cell 172, 1022–1037.
AbstractBöttcher, J.P., Zelenay, S., Rogers, N.C., Helft, J., Schraml, B.U., Reis e Sousa, C., 2015. Oncogenic Transformation of Dendritic Cells and Their Precursors Leads to Rapid Cancer Development in Mice. The Journal of Immunology 195, 5066–5076.
AbstractBöttcher, J.P.*, Beyer, M.*, Meissner, F., Abdullah, Z., Sander, J., Höchst, B., Eickhoff, S., Rieckmann, J.C., Russo, C., Bauer, T., Flecken, T., Giesen, D., Engel, D., Jung, S., Busch, D.H., Protzer, U., Thimme, R., Mann, M., Kurts, C., Schultze, J.L., Kastenmüller, W., Knolle, P.A., 2015. Functional classification of memory CD8(+) T cells by CX3CR1 expression. Nature Communications 6, 8306.
*equal contribution
AbstractBöttcher, J.P.*, Schanz, O.*, Garbers, C., Zaremba, A., Hegenbarth, S., Kurts, C., Beyer, M., Schultze, J.L., Kastenmüller, W., Rose-John, S., Knolle, P.A., 2014. IL-6 trans-signaling-dependent rapid development of cytotoxic CD8+ T cell function. Cell Reports 8, 1318–1327.
*equal contribution
AbstractBöttcher, J.P., Schanz, O., Wohlleber, D., Abdullah, Z., Debey-Pascher, S., Staratschek-Jox, A., Höchst, B., Hegenbarth, S., Grell, J., Limmer, A., Atreya, I., Neurath, M.F., Busch, D.H., Schmitt, E., van Endert, P., Kolanus, W., Kurts, C., Schultze, J.L., Diehl, L., Knolle, P.A., 2013. Liver-primed memory T cells generated under noninflammatory conditions provide anti-infectious immunity. Cell Reports 3, 779–795.
Abstract