Dr. Kathrin Castiglione
Academic Career and Research Areas
Dr. Castiglione (b. 1982, née Hoelsch) works on the development of novel platform technologies for multi-enzyme syntheses. These technologies should help to overcome common limitations of using whole cells or isolated enzymes in biocatalytic processes.
Dr. Castiglione studied Molecular Biotechnology at the TUM (2006). After obtaining her PhD in 2009 at the Institute of Biochemical Engineering of the TUM, she worked as a postdoc at the Toyama Prefectural University in Japan, which was funded by a fellowship from the Japan Society for the Promotion of Science (JSPS). Subsequently, she returned to the Institute of Biochemical Engineering of the TUM and became the leader of the Biocatalysis Group. Since 2012 she leads a BMBF-funded Junior Research Group.
- BMBF-funded Junior Research Group (2012)
- JSPS Postdoctoral Fellowship (2010)
- Nomination for the Bertha-Benz-Preis (2010)
- Stipend from the Prof. Wilhelm Wittmansche Stipendienstiftung (2002-2006)
- Karl-von-Frisch Prize (2001)
Sührer I, Haslbeck M, Castiglione K: Asymmetric synthesis of a Fluoxetine precursor with an artificial fusion protein of a ketoreductase and a formate dehydrogenase. Proc. Biochem. 2014; 49: 1527-1532.Abstract
Klermund L, Groher A, Castiglione K: New N-acyl-D-glucosamine 2-epimerases from cyanobacteria with high activity in the absence of ATP and low inhibition by pyruvate. J. Biotechnol. 2013; 168: 256-263.Abstract
Hölsch K, Sührer I, Heusel M, Weuster-Botz D: Engineering of formate dehydrogenase: Synergistic effect of mutations affecting cofactor specificity and chemical stability. Appl. Microbiol. Biotechnol. 2013; 97: 2473-2481.Abstract
Hölsch K, Weuster-Botz D: New oxidoreductases from cyanobacteria: exploring nature’s diversity. Enz. Microbial Technol. 2010; 47: 228-235.Abstract
Hölsch K, Weuster-Botz D: Enantioselective reduction of prochiral ketones by engineered bifunctional fusion proteins. Biotechnol. Appl. Biochem. 2010; 56: 131-140.Abstract