Priv.-Doz. Dr. med. Philipp J. Jost
Academic Career and Research Areas
PD Dr. Jost´s (*1973) area of interest is molecular medicine and immunology with a specific focus on the process of programmed cell death (termed apoptosis). His team wants to understand the function of pro-survival proteins from the Bcl-2 family for tumor cell initiation and tumor maintenance in the context of the whole organism. Another focus of his work is the non-apoptotic function of cell death proteins, especially from the inhibitor of apoptosis protein family (IAP) and their role in the immune system.
He studied Medicine in Berlin and Munich, defended his thesis (M.D.) in London (2003) and received his associate professorship (Habilitation) at the TUM (2012). A postdoc fellowship from the Deutsche Krebshilfe brought him to Prof. A. Strasser at the Walter and Eliza Hall Institute for Medical Research in Melbourne, Australia (2007-09). Since his return to the TUM, he is junior group leader of a Max Eder-Research Group funded by the Deutsche Krebshilfe at the III. Medical Department at the TUM (2010).
Stipendium der Translational Research Training in Hematology (TRTH) (2011)
Max Eder-Stipendium, Deutsche Krebshilfe (2010)
Postdoc-Stipendium der Dr. Mildred Scheel-Foundation/DKH (2007)
European Cystic Fibrosis Fellowship for Young Scientists (2001)
Aufnahme in die Studienstiftung des deutschen Volkes (1996)
Key Publications (all publications)
Höckendorf U*, Yabal M*, Herold T, Munkhbaatar E, Rott S, Jilg S, Kauschinger J, Magnani G, Reisinger F, Heuser M, Kreipe H, Sotlar K, Engleitner T, Rad R, Weichert W, Peschel C, Ruland J, Heikenwalder H, Spiekermann K, Slotta-Huspenina J, Groß O, Jost PJ: "RIPK3 restricts myeloid leukemogenesis by promoting cell death and differentiation of leukemia initiating cells". Cancer Cell. 2016; 30: 75-91.
Yabal M, Müller N, Adler H, Knies N, Groß CJ, Damgaard RB, Kanegane H, Ringelhan M, Kaufmann T, Heikenwälder M, Strasser A, Groß O, Ruland J, Peschel C, Gyrd-Hansen M, Jost PJ: "XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation". Cell Rep. 2014; 7: 796-808.
Damgaard RB*, Nachbur U*, Yabal M*, Wong WWL, Fiil BK, Kastirr M, Rieser E, Rickard JA, Bankovacki A, Peschel C, Ruland J, Bekker-Jenser S, Mailand N, Kaufmann T, Strasser A, Walczak H, Silke J, Jost PJ*#, Gyrd-Hansen M*# (*:equal contribution; #: corresponding author). "The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity". Molecular Cell, 2012, 46 (6):746-758.Abstract
Vikstrom I, Carotta S, Luthje K, Peperzak V, Jost PJ, Glaser S, Busslinger M, Bouillet P, Strasser A, Nutt SL, Tarlinton DM: “Mcl-1 is Essential for Germinal Center Formation and B Cell Memory”. Science. 2010; 330 (6007): 1095-9.Abstract
Jost PJ, Grabow S, Gray D, McKenzie MD, Nachbur U, Huang DC, Bouillet P, Thomas HE, Borner C, Silke J, Strasser A, Kaufmann T: “XIAP discriminates between type I and type II FAS-induced apoptosis”. Nature. 2009; (460): 1035-1039.Abstract