Persönlicher Status und Werkzeuge

Prof. Dr. Juliane Winkelmann

Full Professor

Neurogenetics

Contact Details

Business card at TUMonline

Academic Career and Research Areas

The research of Juliane Winkelmann focuses on the genetic architecture and underlying molecular mechanisms of complex genetic neurological disorders with a special focus on movement and sleep disorders. Winkelmann and her team have made primary discoveries of genetic variants for common neurological disorders including Restless Leg Syndrome and Dystonia. Her research at the Institute of Neurogenomics (ING) is laying the groundwork for personalized medicine. Through an understanding of genetic predisposition to disease her aim is to be able to prevent disease in individuals and provide superior diagnostic information, paving the way for therapies tailored to the individual patient.

Winkelmann studied medicine at Semmelweis University in Budapest, Hungary, and at LMU Munich. Her doctoral research was conducted at the Max Planck Institute of Psychiatry. She was Professor of Neurology and Neuroscience at Stanford University in California before being appointed Chair of Neurogenetics at TUM in 2015. Since 2017 she has been Senior Vice President International Alliances and Alumni.

    Awards

    • Dingebauer Award, German Society of Neurology (2014)
    • Collaborative Research Award International RLS Study Group (2013)
    • Outstanding Scientific Achievement Award, Sleep Research Society, USA (2009)

    Key Publications

    Zech M, Lam DD, Francescatto L, Schormair B, Salminen AV, Jochim A, Wieland T, Lichtner P, Peters A, Gieger C, Lochmüller H, Strom TM, Haslinger B, Katsanis N, Winkelmann J: “Recessive Mutations in the α3 (VI) Collagen Gene COL6A3 Cause Early-Onset Isolated Dystonia”. Am J Hum Genet. 2015; 96(6): 883-93.

    Abstract

    Spieler D, Kaffe M, Knauf F, Bessa J, Tena JJ, Giesert F, Schormair B, Tilch E, Lee H, Horsch M, Czamara D, Karbalai N, von Toerne C, Waldenberger M, Gieger C, Lichtner P, Claussnitzer M, Naumann R, Müller-Myhsok B, Torres M, Garrett L, Rozman J, Klingenspor M, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Beckers J, Hölter SM, Meitinger T, Hauck SM, Laumen H, Wurst W, Casares F, Gómez-Skarmeta JL, Winkelmann J: “Restless legs syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon”. Genome Res. 2014; 24(4): 592-603.

    Abstract

    Winkelmann J, Czamara D, Schormair B, Knauf F, Schulte EC, Trenkwalder C, Yves Dauvilliers Y, Polo O, Högl B, Berger K, Fuhs A, Gross N, Stiasny-Kolster K, Wolfgang Oertel W, Bachmann CG, Paulus W, Xiong L, Montplaisir J, Rouleau GA, Fietze I, Jana Vávrová J, David Kemlink D, Sonka K, Nevsimalova S, Lin S-C, Wszolek Z, Carles Vilarino-Guell C, Farrer M, Viola Gschliesser V, Birgit Frauscher B, Tina Falkenstetter T, Werner Poewe W, Allen RP, Earley CJ, Ondo WG, Le, Spieler D, Kaffe M, Zimprich A, Kettunen J, Perola M, Silander K, Cournu-Rebeix I, Francavilla M, Fontenille C, Fontaine B, Vodicka P, Lichtner P, Peppard P, Faraco J, Mignot E, Gieger Ch, Illig Th, Wichmann H-E, Müller-Myhsok B, Meitinger T: ”Genome-wide association study identifies novel Restless Legs Syndrome susceptibility loci on 2p14 and 16q12.1”. PLOS GENETICS. 2011; 7(7): e1002171.

    Abstract

    Schormair B*, Kemlink D*, Roeske D, Eckstein G, Xiong L, Lichtner P, Trenkwalder C, Zimprich A, Högl , Poewe W, Stiasny-Kolster K, Oertel W, Bachmann CG, Paulus W, Peglau I, Vodicka P, Vávrová J, Sonka K, Montplaisir J, Turecki G, Rouleau G, Gieger C, Thomas Illig, H-Erich Wichmann H-E, Holsboer F, Müller- Myhsok B, Thomas Meitinger T, Winkelmann J: “Protein-tyrosine Phosphatase Receptor Type Delta (PTPRD) is Associated with Restless Legs Syndrome”. Nature Genetics. 2008; 40: 946-948.

    Abstract

    Winkelmann J, Schormair B, Lichtner P, Ripke S, Xiong L, Jalilzadeh S, Fulda S, Putz B, Eckstein G, Hauk S, Trenkwalder C, Zimprich A, Stiasny-Kolster K, Oertel W, Bachmann CG, Paulus W, Peglau I, Eisensehr I, Montplaisir J, Turecki G, Rouleau G, Gieger C, Illig T, Wichmann HE, Holsboer F, Muller-Myhsok B, Meitinger T: “Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions”. Nature Genetics. 2007; 39(8): 1000-1006.

    Abstract