Academic Career and Research Areas
The research of Professor Ziegler (b. 1958) focuses primarily on the understanding of the natural history of type 1 diabetes in humans, the identification of the mechanisms and predictive markers of the disease and the translation of findings into trials to prevent type 1 diabetes. Another major focus area is the elucidation of the impact of gestational diabetes and maternal hyperglycemia on the long term risk of obesity and type 2 diabetes in mothers and their offspring.
Professor Ziegler studied medicine at LMU Munich. After obtaining her license to practice medicine and receiving her doctorate from LMU, she worked as a research fellow at the Joslin Diabetes Center in Boston, USA (1987-89). She was awarded the prestigious Heisenberg Career Development Award of the German Research Foundation (DFG) (1993), acquired her German medical board certification in internal medicine (1991) and endocrinology (1994) and subsequently became adjunct professor at LMU Munich (1998). From 2007 to 2009 she was Director of the Department of Endocrinology at Klinikum Schwabing in Munich. At the beginning of 2010, she was appointed to the Chair of Diabetes and Gestational Diabetes at the TUM university hospital, Klinikum rechts der Isar, and became Director of the newly founded Institute for Diabetes Research at the Helmholtz Zentrum München. She has been President of the Immunology of Diabetes Society since 2017.
- George Eisenbarth Award for Type 1 Diabetes Prevention of the JDRF (2018)
- Werner Creutzfeldt Award of the German Diabetes Society (2018)
- Brownlee Lecture Award, Joslin Diabetes Center, Boston, USA (2014)
- Mary Tyler Moore and S. Robert Levine Excellence in Clinical Research Award, Juvenile Diabetes Research Foundation (2013)
- Heisenberg Career Development Award of the German Research Foundation (DFG) (1993)
Key Publications (all publications)
Bonifacio E, Beyerlein A, Hippich M, Winkler C, Vehik K, Weedon MN, Laimighofer M, Hattersley AT, Krumsiek J, Frohnert BI, Steck AK, Hagopian WA, Krischer JP, Lernmark Å, Rewers MJ, She JX, Toppari J, Akolkar B, Oram RA, Rich SS, Ziegler AG; TEDDY Study Group: "Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children". PLoS Medicine. 2018; 15(4): e1002548.Abstract
Beyerlein A, Donnachie E, Jergens S, Ziegler AG: "Infections in Early Life and Development of Type 1 Diabetes". JAMA. 2016; 315(17): 1899-901.Abstract
Ziegler AG, Rewers M, Simell O, Simell T, Lempainen J, Steck A, Winkler C, Ilonen J, Veijola R, Knip M, Bonifacio E, Eisenbarth GS: "Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children". JAMA. 2013; 309(23): 2473-2479.Abstract
Hummel M, Bonifacio E, Schmid S, Walter M, Knopff A, Ziegler AG: "Early appearance of islet autoantibodies predicts childhood type 1 diabetes in offspring of diabetic parents". Annals of Internal Medicine. 2004; 140(11): 882-886.Abstract
Ziegler AG, Schmid S, Huber D, Hummel M, Bonifacio E: “Early infant feeding and risk of developing type 1 diabetes-associated autoantibodies”. JAMA. 2003; 290: 1721-1728.Abstract