TUM – Technical University of Munich Menü

Prof. Dr. Günter U. Höglinger

Academic Career and Research Areas

Professor Höglinger (b. 1971) conducts research in the field of neurodegenerative Parkinson syndromes with the goal of understanding the molecular mechanisms leading to the development and progression of neuronal dysfunction and death and of using these findings for diagnostic and therapeutic purposes. His particular focus is the interface between preclinical and clinical research.

Günter Höglinger studied medicine and physics at the universities of Regensburg and Würzburg. He earned his PhD in medicine, summa cum laude, in 2000. Supported by a grant from the German Research Foundation, DFG, he worked as a postdoctoral researcher at the Hôpital de la Salpêtrière in Paris. Since 2004 he has directed the experimental neurology research group at Philipps University Marburg. In Marburg he also acquired his German medical board certification in neurology and went on to work as the Vice Director of the Department of Neurology. Since 2011 he has worked as a senior consultant at TUM’s Department of Neurology and holds the Chair of the Department of Translational Neurodegeneration at the German Center for Neurodegenerative Diseases, DZNE. From 2019 on, he is the President of the German Parkinson Association.


  • Dingebauer Award of the German Society for Neurology (DGN) (2017)
  • National PSP Award, German PSP Sociey (2012)
  • Heisenberg Professorship of the German Research Association (DFG) (2011)
  • Innovation award of the Walter & Luise Freundlich-Foundation (2009)
  • Award for Excellence of the Movement Disorders Society (2007)

Key Publications

Weber A, Höglinger GU: "Epigenome-wide DNA methylation profiling in Progressive Supranuclear Palsy reveals major changes at DLX1". Nature Communications. 2018; 9 (1): 2929.


Boxer AL, Höglinger GU: "Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches". The Lancet Neurology. 2017; 16:552-563.


Höglinger GU, Schellenberg JD: "Identification of common variants influencing risk of the tauopathy Progressive Supranuclear Palsy." Nature Genetics. 2011;43: 699-705.


Höglinger GU, Hunot S.: "The pRb/E2F cell-cycle pathway mediates cell death in Parkinson’s disease." Proc Natl Acad Sci U S A. 2007;104: 3585–3590.


Höglinger GU, Hirsch EC.: "Dopamine depletion impairs precursor cell proliferation in Parkinson disease." Nature Neuroscience. 2004;7: 726-735.