Academic Career and Research Areas

Dr. Sebastian Lobentanzer trained as a pharmacist and completed a PhD in pharmacology and toxicology. He subsequently worked as a postdoctoral researcher at Heidelberg University Hospital and as a PI with Open Targets at the European Bioinformatics Institute (EMBL-EBI). Since 2025, he is a tenure-track research group leader at Helmholtz Munich and serves as Head of Computational Biology at the German Center for Diabetes Research.

Dr. Lobentanzer’s research focuses on developing accessible, robust, and interpretable artificial intelligence methods for biomedical discovery. Contemporary biomedicine generates vast and heterogeneous datasets, yet much of this information remains underutilised due to fragmentation and limited accessibility of computational methods. Sebastian’s work addresses this challenge by combining biomedical expertise with research software engineering to build digital infrastructure that makes biomedical workflows AI-ready. His main research interests include biomedical knowledge representation, epistemic robustness of agentic AI, and open, community-driven research software.

Kuehl M et al.: "BioContextAI is a community hub for agentic biomedical systems". Nature Biotechnology. 2025

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Jarchow H et al.: "Benchmarking Large Language Models for Personalized and Biomarker-Based Intervention Recommendations". npj Digital Medicine. 2025

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Lobentanzer S et al.: "A platform for the biomedical application of large language models". Nature Biotechnology. 2025

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Lobentanzer S et al.: "Molecular causality in the advent of foundation models". Molecular Systems Biology. 2024

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Lobentanzer S et al.: "Democratizing knowledge representation with BioCypher". Nature Biotechnology. 2023

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