Dr. Klaus Richter
TUM Junior Fellow
Academic Career and Research Areas
Dr. Klaus Richter (b. 1973) conducts research in the area of cellular signal transduction and the influence of molecular chaperones. This interaction plays a role in many diseases, such as the activation of oncogenic kinases, the misregulation of gene expression, the loss of anchoring structures of muscle cells or in cellular protein aggregation, which occurs during the development of neurodegenerative diseases. We investigate concepts about the interaction of these proteins in model systems such as C.elegans, yeast, or mammalian cells. We want to reveal how the disease patterns develop and how better regulation of the chaperone interaction could have a positive effect.
Dr. Klaus Richter studied biochemistry at the University of Regensburg and graduated at the Technical University of Munich. Here, he devoted himself to the ATP hydrolysis of the chaperone Hsp90. This was followed by a time at Northwestern University Chicago, where Mr. Richter investigated the regulation of the heat shock response in the model organism C. elegans. Building on these results, Mr. Richter founded his junior research group at the TU Munich.
- Curriculum Vitae
- Heisenberg-Fellowship (2017)
- DAAD-Fellowship (2004)
- DAAD-Fellowship (1997)
Key Publications (all publications)
Eckl, J., Daake, M., Schwartz, S. & Richter, K. Nucleotide-free sB-Raf is preferentially bound by Hsp90 and Cdc37 in vitro. (2016), J. Mol. Biol. 428(20):4185-4196.Abstract
Haslbeck, V., Eckl, J.M., Drazic, A., Rutz, D.A., Lorenz, O.R., Zimmermann, K., Kriehuber, T., Lindemann, C., Madl, T. & Richter, K. The activity of protein phosphatase 5 towards native clients is modulated by the middle- and C-terminal domains of Hsp90. (2015), Sci Rep. 5:17058, 1-16.Abstract
Papsdorf, K., Kaiser, C.J., Drazic, A., Grötzinger, S.W., Haeßner, C., Eisenreich, W. & Richter, K. Polyglutamine toxicity in yeast induces metabolic alterations and mitochondrial defects. (2015), BMC Genomics 16-662, 1-18.Abstract
Papsdorf, K., Sacherl, J. & Richter, K. The balanced regulation of Hsc70 by DNJ-13 and UNC-23 is required for muscle functionality. (2014), J Biol Chem. 289, 25250-25261Abstract
Kaiser, C.J., Grötzinger, S.W, Eckl, J.W., Papsdorf, K., Jordan, S. & Richter, K. A network of genes connects polyglutamine toxicity to ploidy control in yeast. (2013), Nat Commun 4, 1571.Abstract v