Prof. Dr. Bernhard Küster
Academic Career and Research Areas
Professor Küster (*1967) conducts research in the fields of chemical proteomics and precision medicine. Together with an interdisciplinary team of biochemists, molecular biologists and bioinformaticians, he deals with questions about how exactly therapeutic drugs work, which molecular mechanisms play a role in cancer and how these can be used for individual approaches in clinical treatment.
After studying chemistry at the University of Cologne, Professor Küster completed his doctorate in biochemistry at the University of Oxford. He then worked as a postdoctoral researcher in Heidelberg and Odense, Denmark. Before taking up a full professorship at TUM in 2007, he was Vice President of Cellzome (now GSK). Professor Küster is Director of the Bavarian Biomolecular Mass Spectrometry Center and Co-Director of the Center for Infection Prevention. Professor Küster is co-founder of the biotech companies OmicScouts and MSAID.
Awards
- The Barry L. Karger Medal in Analytical Chemistry, Northeastern University, Boston, USA (2025)
- Distinguished Achievement in Proteomic Sciences Award, Human Proteome Organization (2023)
- Member of the German National Academy of Science Leopoldina (2021)
- ERC Advanced Grant (2019)
- Discovery in Proteomic Sciences Award, Human Proteome Organization (2015)
Key Publications (all publications)
Eckert, S., Berner, N., Kramer, K., Schneider, A., Müller, J., Lechner, S., Brajkovic, S., Sakhteman, A., Graetz, C., Fackler, J., Dudek, M., Pfaffl, M. W., Knolle, P., Wilhelm, S. & Kuster, B.: „Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics“. Nat Biotechnol. 43: 406–415.
AbstractZecha, J., Bayer, F. P., Wiechmann, S., Woortman, J., Berner, N., Müller, J., Schneider, A., Kramer, K., Abril-Gil, M., Hopf, T., Reichart, L., Chen, L., Hansen, F. M., Lechner, S., Samaras, P., Eckert, S., Lautenbacher, L., Reinecke, M., Hamood, F., Prokofeva, P., Vornholz, L., Falcomatà, C., Dorsch, M., Schröder, A., Venhuizen, A., Wilhelm, S., Médard, G., Stoehr, G., Ruland, J., Grüner, B. M., Saur, D., Buchner, M., Ruprecht, B., Hahne, H., The, M., Wilhelm, M., Kuster, B.: „Decrypting drug actions and protein modifications by dose- and time-resolved proteomics“. Science. 2023; 380: 93-101.
AbstractMergner, J., Frejno, M., List, M., Papacek, M., Chen, X., Chaudhary, A., Samaras, P., Richter, S., Shikata, H., Messerer, M., Lang, D., Altmann, S., Cyprys, P., Zolg, D. P., Mathieson, T., Bantscheff, M., Hazarika, R. R., Schmidt, T., Dawid, C., Dunkel, A., Hofmann, T., Sprunck, S., Falter-Braun, P., Johannes, F., Mayer, K. F. X., Jürgens, G., Wilhelm, M., Baumbach, J., Grill, E., Schneitz, K., Schwechheimer, C. & Kuster, B.: “Mass spectrometry-based draft of the Arabidopsis proteome”. Nature. 2020; 579: 409-414.
AbstractKlaeger S, Heinzlmeir S, Wilhelm M, Polzer H, Vick B, Koenig PA, Reinecke M, Ruprecht B, Petzoldt S, Meng C, Zecha J, Reiter K, Qiao H, Helm D, Koch H, Schoof M, Canevari G, Casale E, Re Depaolini S, Feuchtinger A, Wu Z, Schmidt T, Rueckert L, Becker W, Huenges J, Garz AK, Gohlke BO, Zolg DP, Kayser G, Vooder T, Preissner P, Hahne H, Tonisson N, Kramer K, Goetze K, Bassermann F, Schlegl J, Ehrlich HC, Aiche S, Walch A, Greif P, Schneider S, Felder ER, Ruland J, Medard G, Jeremias I, Spiekermann K, Kuster B: „The target landscape of clinical kinase drugs“.Science. 2017; 358:pii: eaan4368.
AbstractWilhelm M, Schlegl J, Hahne H, Moghaddas Gholami A, Lieberenz M, Savitski MM, Ziegler E, Butzmann L, Gessulat S, Marx H, Mathieson T, Lemeer S, Schnatbaum K, Reimer U, Wenschuh H, Mollenhauer M, Slotta-Huspenina J, Boese JH, Bantscheff M, Gerstmair A, Faerber F, Kuster B: „Mass spectrometry based draft of the human proteome“. Nature. 2014; 509: 582-587.
AbstractIf you wish your profile to be changed or updated please contact Franz Langer.