Prof. Dr. Bernhard Küster

Academic Career and Research Areas

Professor Küster (b. 1967) conducts research in the fields of proteomics and precision medicine. Together with an interdisciplinary team of chemists, biologists and bioinformaticians, his research focuses on questions relating to how therapeutic drugs work, which molecular mechanisms play a role in cancer and how these can be used for individual approaches to clinical treatment.

After studying chemistry at the University of Cologne, Professor Küster obtained his doctorate in biochemistry at the University of Oxford. He subsequently worked as a postdoctoral researcher in Heidelberg, Germany, and Odense, Denmark. Prior to becoming a full professor at TUM in 2007, he was Vice President of Cellzome (now GSK). Professor Küster is Vice Dean of Information Management at TUM School of Life Sciences and Director of the Bavarian Biomolecular Mass Spectrometry Center. Professor Küster is a founder of the biotech companies OmicScouts and MSAID.

Awards

  • Carl von Linde Senior Fellow, TUM Institute for Advanced Study (2018)
  • Discovery in Proteomic Sciences Award, Human Proteome Organization (2015)
  • Heinz Maier-Leibnitz Medal, TUM (2014)
  • Long-term fellow, European Molecular Biology Organization (1998)
  • Mattauch-Herzog Award, German Mass Spectrometry Society (1998)

Jarzab, J., Kurzawa, N., Hopf, T., Moerch, M., Zecha, J., Leijten, N., Bian, Y., Musiol, E., Maschberger, M., Stoehr, G., Becher, I., Daly, C., Samaras, P., Mergner, J., Spanier, B., Angelov, A., Werner, T., Bantscheff, M., Wilhelm, M., Klingenspor, M., Lemeer, S., Liebl, W., Hahne, H., Savitski, M. M. & Kuster, B.: “Meltome Atlas – thermal proteome stability across the tree of life”. Nat Methods. 2020; 17: 495-503.

Abstract

Mergner, J., Frejno, M., List, M., Papacek, M., Chen, X., Chaudhary, A., Samaras, P., Richter, S., Shikata, H., Messerer, M., Lang, D., Altmann, S., Cyprys, P., Zolg, D. P., Mathieson, T., Bantscheff, M., Hazarika, R. R., Schmidt, T., Dawid, C., Dunkel, A., Hofmann, T., Sprunck, S., Falter-Braun, P., Johannes, F., Mayer, K. F. X., Jürgens, G., Wilhelm, M., Baumbach, J., Grill, E., Schneitz, K., Schwechheimer, C. & Kuster, B.: “Mass spectrometry-based draft of the Arabidopsis proteome”. Nature. 2020; 579: 409-414.

Abstract

Klaeger S, Heinzlmeir S, Wilhelm M, Polzer H, Vick B, Koenig PA, Reinecke M, Ruprecht B, Petzoldt S, Meng C, Zecha J, Reiter K, Qiao H, Helm D, Koch H, Schoof M, Canevari G, Casale E, Re Depaolini S, Feuchtinger A, Wu Z, Schmidt T, Rueckert L, Becker W, Huenges J, Garz AK, Gohlke BO, Zolg DP, Kayser G, Vooder T, Preissner P, Hahne H, Tonisson N, Kramer K, Goetze K, Bassermann F, Schlegl J, Ehrlich HC, Aiche S, Walch A, Greif P, Schneider S, Felder ER, Ruland J, Medard G, Jeremias I, Spiekermann K, Kuster B: „The target landscape of clinical kinase drugs“. Science. 2917; 358: pii: eaan4368

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Zolg DP, Wilhelm M, Schnatbaum K, Zerweck J, Knaute T, Delanghe B, Bailey DJ, Gessulat S, Ehrlich HC, Weininger M, Yu Y, Schlegl J, Kramer K, Schmidt T, Kusebauch U, Deutsch EW, Aebersold R, Moritz RL, Wenschuh H, Moehring T, Aiche S, Huhmer A, Reimer U, Kuster B: “Building Proteometools based on a complete synthetic human proteome”. Nature Methods. 2017; 14: 259-262.

Abstract

Wilhelm M, Schlegl J, Hahne H, Moghaddas Gholami A, Lieberenz M, Savitski MM, Ziegler E, Butzmann L, Gessulat S, Marx H, Mathieson T, Lemeer S, Schnatbaum K, Reimer U, Wenschuh H, Mollenhauer M, Slotta-Huspenina J, Boese JH, Bantscheff M, Gerstmair A, Faerber F, Kuster B: „Mass spectrometry based draft of the human proteome“. Nature. 2014; 509: 582-587.

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