Persönlicher Status und Werkzeuge

Academic Career and Research Areas

Prof. Küster’s (b. 1967) research field is chemical and functional proteomic analysis. The main areas he explores are how proteins interact with each other and with active pharmaceutical ingredients, which molecular mechanisms play a role in cancer and how these can be used for individual approaches to clinical treatment. To aid his research, he uses methodologies drawn from biochemistry and molecular biology as well as spectroscopic high-throughput methods.

After studying chemistry at the University of Cologne, Prof. Küster obtained his doctorate in biochemistry at the University of Oxford. He worked as a postdoctoral researcher under Prof. Matthias Mann in Heidelberg and in Odense, Denmark. Prior to becoming a full professor at TUM, he was Vice President of the biotech firm Cellzome AG in Heidelberg until 2007. Prof. Küster is a member of several academic and industry science advisory boards. He is also on the editorial board of a number of scientific journals. He plays an active role in the German Chemical Society (GDCh), the German Society for Mass Spectrometry (DGMS) and the German Society for Proteome Research (DGPF).

Awards

Visiting Professor, University of Bergen (2009)

Mattauch Herzog Preis der DGMS (1998)

Key Publications (all publications)

Bantscheff M, Eberhard D, Abraham Y, Bastuck S, Boesche M, Hobson S, Mathieson T, Perrin J, Raida M, Rau C, Reader V, Sweetman G, Bauer A, Bouwmeester T, Hopf C, Kruse U, Neubauer G, Ramsden N, Rick J, Kuster B, Drewes G: “A quantitative chemical proteomics approach reveals novel modes of action of clinical ABL kinase inhibitors“. Nat. Biotechnol. 2007; 25: 1035-1044.

Abstract

Gavin AC, Aloy P, Grandi P, Krause R, Boesche M, Marzioch M, Rau C, Jensen LJ, Bastuck S, Dumpelfeld B, Edelmann A, Heurtier MA, Hoffman V, Hoefert C, Klein K, Hudak M, Michon AM, Schelder M, Schirle M, Remor M, Rudi T, Hooper S, Bauer A, Bouwmeester T, Casari G, Drewes G, Neubauer G, Rick JM, Kuster B, Bork P, Russell RB, Superti-Furga G: “Proteome survey reveals modularity of the yeast cell machinery”. Nature. 2006; 440: 631-636.

Abstract

Kuster B, Schirle M, Mallick P, Aebersold R: “Scoring proteomes with proteotypic peptide probes”. Nat. Rev. Mol. Cell Biol. 2005; 6: 577-583.

Abstract

Schirle M, Heurtier MA, Kuster B: “Profiling core proteomes of human cell lines by 1D PAGE and LC-MS/MS”. Mol Cell Proteomis. 2003; 2: 1297-1305.

Küster B, Wheeler SF, Hunter AP, Dwek RA, Harvey DJ: “Sequencing of N-linked oligosaccharides directly from protein gels”. Anal. Biochem. 1997; 250: 82-101.

Abstract