Prof. Dr. Matthias Rief


Molecular Biophysics

Academic Career and Research Areas

The focus of Professor Rief’s research is molecular biophysics.
After studying physics at TUM (1995) and receiving a doctoral degree at Ludwig Maximilian University in Munich, Professor Rief worked as a post-doc at Stanford University (USA) from 1998 to 2000. Prior to his appointment to the Chair of Molecular Biophysics at TUM (2003), he was a visiting professor (2000-2001) and later an associate professor at Ludwig Maximilian University.


  • Nanoscience Prize (2003)
  • Heinz Maier-Leibnitz Prize of the German Research Foundation (2000)
  • Annual Prize of the German Society for Biophysics (1999)
  • Doctoral Award of the Ludwig-Maximilians-University Munich (1999)

Gebhardt JC, Bornschlogl T, Rief M: "Full distance-resolved folding". Proc. Natl. Acad. Sci. 2010; 107: 2013-2018.


Junker  JP, F Ziegler, M Rief: "Ligand-dependent equilibrium fluctuations of single calmodulin molecules". Science. 2009; 323: 633-637.


Bertz M, Wilmanns M, Rief M: "The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk". Proc. Natl. Acad. Sci. 2009; 106: 13307-133310.


Dietz H, Berkemeier F, Bertz M, Rief M: "Anisotropic deformation response of single protein molecules". Proc. Natl. Acad. Sci. 2006; 103:12724-12728.


Rief M, Gautel M, Oesterhelt F, Fernandez JM, Gaub HE: "Reversible unfolding of individual titin immunoglobulin domains by AFM". Science. 1997; 276: 1109-1112.