Academic Career and Research Areas
Professor Buchner (b. 1960) carries out research into the principals of the structural formation of proteins and the cellular machinery of protein folding which also allows survival in adverse environmental conditions (such as high temperatures). In addition to providing an insight into fundamental cellular processes, these studies provide valuable information about the conditions required for the production of proteins in biotechnological processes, i.e. for the biosynthesis of antibodies whose molecular basis has been clarified.
After studying biology at the University of Regensburg, Professor Buchner completed his PhD at the same university in 1991. Subsequently, he worked as a postdoctoral researcher on new concepts for cancer therapy with Ira Pastan at the National Cancer Institute of the National Institute of Health (NIH), USA. He then returned to the University of Regensburg to head a junior research group. He acquired his postdoctoral teaching qualification (habilitation) in 1995 in the field of biochemistry and in 1998 became a professor at TUM. Professor Buchner is one of the organizers of the Cluster of Excellence “Center for Integrated Protein Science Munich” (CIPSM) and on the advisory board of the German Society for Biochemistry and Molecular Biology (GBM).
- Hans Neurath Preis der Protein Society (2011)
- Wahl in die Bayerische Akademie der Wissenschaften (2010)
- Wahl in die Leopoldina (2006)
- Habilitationspreis (1995)
- Heisenbergstipendium (1995)
Key Publications (all publications)
Kazman P, Vielberg M-T, Pulido Cendales MD, Hunziger L, Weber B, Hegenbart U, Zacharias M, Köhler R, Schönland S, Groll M, & Buchner J: “A patient-derived antibody light chain shows fatal amyloid formation caused by a single point mutation”. Elife. 2020; 9: e52300.Abstract
Dahiya V, Agam G, Lawatscheck J, Rutz DA, Lamb DC, and Buchner J: “Coordinated conformational processing of p53 by the Hsp70 and Hsp90 chaperones machineries”. Mol. Cell. 2019; 74: 816-830.Abstract
Schmid PWN, Lim NCH, Peters C, Back KC, Bourgeois B, Pirolt F, Richter B, Peschek J, Puk O, Amarie OV, Dalke C, Haslbeck M, Weinkauf S, Madl T, Graw J & Buchner J: “Imbalances in the eye lens proteome are linked to cataract formation”. Nature Struct. & Mol. Biol. 2011; 28: 143–151.Abstract
Feige MJ, Groscurth S, Marcinowski M, Shimizu Y, Kessler H, Hendershot LM, Buchner J.: “An unfolded CH1 domain controls the assembly and secretion of IgG antibodies”. Mol. Cell. 2009; 34: 569-579.Abstract
Bose S, Weikl T, Bügl H, Buchner J: “Chaperone function of Hsp90-associated proteins”. Science. 1996; 274: 1715 - 1717.Abstract