Academic Career and Research Areas
Prof. Buchner (*1960) investigates the principles of protein structure formation and the cellular machinery of protein folding, which also allows the cell to survive adverse environmental conditions (such as high temperatures). In addition to providing insight into fundamental cellular processes, these studies also provide important prerequisites for the production of proteins in biotechnological processes, such as the biosynthesis of antibodies, whose molecular basis is being elucidated.
After studying biology at the University of Regensburg, Prof. Buchner received his doctorate there in 1991. As a postdoctoral researcher, he worked with Ira Pastan at the National Cancer Institute of the NIH on new concepts of cancer therapy and subsequently returned to the University of Regensburg as head of a junior research group. There he habilitated in biochemistry in 1995 and was appointed full professor at TUM in 1998. Prof. Buchner was co-organizer and co-spokesperson of the Center for Integrated Protein Science Munich (CIPSM) cluster of excellence and he has led the SFB 1035 on conformational regulation of proteins since 2012).
Key Publications (all publications)
Kazman P, Vielberg M-T, Pulido Cendales MD, Hunziger L, Weber B, Hegenbart U, Zacharias M, Köhler R, Schönland S, Groll M, & Buchner J: “A patient-derived antibody light chain shows fatal amyloid formation caused by a single point mutation”. Elife. 2020; 9: e52300.Abstract
Dahiya V, Agam G, Lawatscheck J, Rutz DA, Lamb DC, and Buchner J: “Coordinated conformational processing of p53 by the Hsp70 and Hsp90 chaperones machineries”. Mol. Cell. 2019; 74: 816-830.Abstract
Schmid PWN, Lim NCH, Peters C, Back KC, Bourgeois B, Pirolt F, Richter B, Peschek J, Puk O, Amarie OV, Dalke C, Haslbeck M, Weinkauf S, Madl T, Graw J & Buchner J: “Imbalances in the eye lens proteome are linked to cataract formation”. Nature Struct. & Mol. Biol. 2011; 28: 143–151.Abstract
Feige MJ, Groscurth S, Marcinowski M, Shimizu Y, Kessler H, Hendershot LM, Buchner J.: “An unfolded CH1 domain controls the assembly and secretion of IgG antibodies”. Mol. Cell. 2009; 34: 569-579.Abstract
Bose S, Weikl T, Bügl H, Buchner J: “Chaperone function of Hsp90-associated proteins”. Science. 1996; 274: 1715 - 1717.Abstract