Academic Career and Research Areas
Prof. Glawischnig’s (*1968) research areas are:
- functional characterization of cytochrome P450 enzymes from plants and formation of metabolic protein complexes, focusing on members of the CYP71 family
- genome editing and targeted mutagenesis of cytochrome P450 genes in plants.
- elucidation of metabolic networks in plant secondary metabolites, focusing on tryptophan-derived defense-compounds
After his diploma in biology and a PhD at TUM, he focused on central metabolism in maize before he went to Prof. Halkier in Copenhagen in 2000 as an EMBO fellow. From 2002 he worked as a group leader at the Chair of Genetics (Prof. Gierl) at TUM and completed his habilitation in 2007. 2012-2017 he headed a Heisenberg research group at the WZW, before moving to the TUM Campus Straubing in 2017. Since 2018 he has been teaching and researching at the Professorship for Microbial Biotechnology (Prof. Blombach).
Key Publications (all publications)
Mucha S, Heinzlmeir S, Kriechbaumer V, Strickland B, Kirchhelle C, Choudhary M, Kowalski N, Eichmann R, Hückelhoven R, Grill E, Kuster B, Glawischnig E.: “The formation of a camalexin-biosynthetic metabolon”. Plant Cell. 2019; 31: 2697-2710.Abstract
Müller TM, Böttcher C, Morbitzer R, Götz CC, Lehmann J, Lahaye T, Glawischnig E: “TALEN-mediated generation and metabolic analysis of camalexin-deficient cyp71a12 cyp71a13 double knockout lines”. Plant Physiology. 2015; 168: 849-858.Abstract
Böttcher C, Westphal L, Schmotz C, Prade E, Scheel D, Glawischnig E.: “The multifunctional enzyme, CYP71B15 (PHYTOALEXIN DEFICIENT 3), converts cysteine-indole-3- acetonitrile to camalexin in the indole-3-acetonitrile metabolic network of Arabidopsis thaliana”. Plant Cell. 2009; 21: 1830-1845.Abstract
Glawischnig E, Hansen BG, Olsen CE, Halkier BA.: “Camalexin is synthesized from indole-3-acetaldoxime, a key branching point between primary and secondary metabolism in Arabidopsis”. Proc Natl Acad Sci USA. 2004; 101: 8245-8250.Abstract
Frey M, Chomet P, Glawischnig E, Stettner C, Grün S, Winklmair A, Eisenreich W, Bacher A, Meeley R, Briggs SP, Simcox K, Gierl A.: “Analysis of a chemical plant defense mechanism in grasses”. Science. 1997; 277: 696-699.Abstract