Professorial Faculty
Technical University of Munich

Prof. Dr. Simon N. Jacob

Professorship

Translational Neurotechnology

School

TUM School of Medicine and Health

Contact Details

Business card at TUMonline

Academic Career and Research Areas

Prof. Jacob (b. 1977) is a neurologist and neurophysiologist. His research focusses on the cellular and circuit basis of cognitive brain functions. Based on his experimental work, Prof. Jacob is developing technologies that can contribute to improving treatments for disorders in the domains of perception, memory and language.

Prof. Jacob studied medicine in Freiburg and Heidelberg, at University College London (UK) and at Harvard University (USA) as a fellow of the German National Academic Foundation. He obtained his medical doctorate degree in 2006 based on experimental neurophysiological work conducted at Yale University (USA). Prof. Jacob was a postdoctoral researcher at the Center for Integrative Neuroscience in Tübingen and qualified as a board-certified neurologist after training in Tübingen and at the Charité in Berlin. In 2015, Prof. Jacob moved to TUM where he established an interdisciplinary research group investigating the neuronal mechanisms of cognitive brain functions. He was appointed professor for Translational Neurotechnology in 2019.

Awards

  • ERC Consolidator Grant (2024)
  • Early Excellence Academy, SyNergy Cluster for Systems Neurology (2023)
  • Speaker TUM Innovation Network NEUROTECH (2021-2026)
  • ERC Starting Grant (2017)
  • Charité Clinical Scientist Award (2014)

Key Publications

Bernklau TW, Righetti B, Mehrke LS, Jacob SN (2024) Striatal dopamine signals reflect perceived cue-action-outcome associations in mice. Nat Neurosci 27(4):747-757.

Abstract

Lin XX, Nieder A, Jacob SN (2023) The neuronal implementation of representational geometry in primate prefrontal cortex. Sci Adv 9:eadh8685.

Abstract

Eisenkolb VM, Held LM, Utzschmid A, Lin XX, Krieg SM, Meyer B, Gempt J, Jacob SN (2023) Human acute microelectrode array recordings with broad cortical access, single-unit resolution and parallel behavioral monitoring. Cell Rep 42(5):112467.

Abstract

Hanganu-Opatz IL, Klausberger T, Sigurdsson T, Nieder A, Jacob SN, Bartos M, Sauer JF, Durstewitz D, Leibold C, Diester I (2023) Resolving the prefrontal mechanisms of adaptive cognitive behaviors: A cross-species perspective. Neuron. 111(7):1020-1036.

Abstract

Ploner M, Buyx A, Gempt J, Gjorgjieva J, Müller R, Priller J, Rückert D, Wolfrum B, Jacob SN (2023) Reengineering neurotechnology: placing patients first. Nat Mental Health. 1(1)5:7.

Abstract

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