Prof. Dr. Natalie Krahmer
Academic Career and Research Areas
Dr. Natalie Krahmer develops proteomic and multi-omic tools to map cellular organization and organelle composition in in vivo models of metabolic disease. Her research examines how lipid accumulation driven by overnutrition alters cellular function. A central scientific question is how organelles and their subpopulations adapt their composition, interactions, and functions to coordinate metabolic pathways in a cell type-specific manner, and how their disruption contributes to metabolic disease, with the aim of identifying therapeutic targets.
Dr. Natalie Krahmer was appointed to a joint professorship between the Technical University of Munich and Helmholtz Munich in 2026. She was selected for the DFG Emmy Noether Programme in 2019 and subsequently established her independent research group at Helmholtz Center Munich. She studied biology and biochemistry at the TUM and obtained her doctorate in biology in 2011 at the Max Planck Institute of Biochemistry in Munich. From 2013 to 2018, she completed postdoctoral training at the Max Planck Institute of Biochemistry.
Awards
- German Helmholtz Society Professorship Award (2025)
- EFSD Novo Nordisk Future Leader Award (2020)
- DFG Emmy Noether Fellowship (2019)
Key Publications (all publications)
Haas, D. T., D. Weindl, P. Kakimoto, E. M. Trautmann, J. P. Schessner, X. Mao, M. J. Gerl, M. Gerwien, T. D. Muller, C. Klose, X. Cheng, J. Hasenauer and N. Krahmer (2026). "C-COMPASS: a user-friendly neural network tool profiles cell compartments at protein and lipid levels." Nat Methods 23(1): 118-130.2).
AbstractKlingelhuber, F., S. Frendo-Cumbo, M. Omar-Hmeadi, L. Massier, P. Kakimoto, A. J. Taylor, M. Couchet, S. Ribicic, M. Wabitsch, A. C. Messias, A. Iuso, T. D. Muller, M. Ryden, N. Mejhert and N. Krahmer (2024). "A spatiotemporal proteomic map of human adipogenesis." Nat Metab 6(5): 861-879.
AbstractKrahmer, N., B. Najafi, F. Schueder, F. Quagliarini, M. Steger, S. Seitz, R. Kasper, F. Salinas, J. Cox, N. H. Uhlenhaut, T. C. Walther, R. Jungmann, A. Zeigerer, G. H. H. Borner and M. Mann (2018). "Organellar Proteomics and Phospho-Proteomics Reveal Subcellular Reorganization in Diet-Induced Hepatic Steatosis." Dev Cell 47(2): 205-221 e207.
AbstractKrahmer, N., Y. Guo, F. Wilfling, M. Hilger, S. Lingrell, K. Heger, H. W. Newman, M. Schmidt-Supprian, D. E. Vance, M. Mann, R. V. Farese, Jr. and T. C. Walther (2011). "Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:phosphocholine cytidylyltransferase." Cell Metab 14(4): 504-515.
AbstractKrahmer, N., M. Hilger, N. Kory, F. Wilfling, G. Stoehr, M. Mann, R. V. Farese, Jr. and T. C. Walther (2013). "Protein correlation profiles identify lipid droplet proteins with high confidence." Mol Cell Proteomics 12(5): 1115-1126.
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