Prof. Dr. Stefan Lichtenthaler



Academic Career and Research Areas

Professor Lichtenthaler (b. 1968) conducts research on the molecular basis of neurodegenerative diseases such as Alzheimer’s disease. The goal is to gain a better understanding of these common forms of dementia, to develop new diagnostic and therapeutic approaches and to be able to better predict the possible side effects of medication. This research is carried out using biochemical and proteomic methods such as quantitative mass spectrometry.

Professor Lichtenthaler studied chemistry at the Universities of Karlsruhe, Montpellier (France) and Heidelberg. He earned his doctoral degree at ZMBH, Heidelberg University’s Center for Molecular Biology. After working as a postdoctoral researcher at Harvard University (USA) he led a junior research group at LMU Munich where he also acquired his postdoctoral teaching qualification (habilitation) for his work in the field of biochemistry. In 2009 he was appointed head of department at DZNE, the newly established German Center for Neurodegenerative Diseases. Since 2012 he has been full professor of proteomics at TUM and DZNE.


  • Alzheimer Research Award of the Hans and Ilse Breuer Foundation (2014)
  • Emmy-Noether grant recipient (1999-2001)
  • Dr. Sophie Bernthsen Prize recipient (1994)

Key Publications

Lichtenthaler SF, Güner G: "Pathology-linked protease caught in action". Science. 2019; 363 (6428), 690-691.


Brummer T, Müller SA, Pan-Montojo F, Fumiaki Y, Fellgiebel A, Tomita T, Endres K, Lichtenthaler SF: "NrCAM is a marker for substrate-selective activation of ADAM10 in Alzheimer's disease". EMBO Molecular Medecine. 2019; e9695


Lichtenthaler SF, Lemberg M, Fluhrer R: "Proteolytic ectodomain shedding of membrane proteins in mammals - hardware, concepts and recent developments". The EMBO Journal. 2018; 37, e99456.


Colombo A, Hsia HE, Wang M, Kuhn PH, Brill MS, Canevazzi P, Feederle R, Taveggia C, Misgeld Th, Lichtenthaler SF: "Non-cell-autonomous function of DR6 in Schwann cell proliferation". The EMBO Journal. 2018; 37(7): e97390.


Kuhn PH, Colombo AV, Schusser B, Dreymueller D, Wetzel S, Schepers U, Herber J, Ludwig A, Kremmer E, Montag D, Müller U, Schweizer M, Saftig P, Bräse S, Lichtenthaler SF: "Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function". eLife. 2016; 5: e12748.