Prof. Dr. Lars Maegdefessel


Vascular Biology

Academic Career and Research Areas

Lars Mägdefessel (b. 1977) is interested in the contribution of non-coding RNAs to vascular disease development and progression. Within vascular pathologies, his research team focuses on atherosclerotic plaque vulnerability and expanding aortic aneurysms, utilizing a variety of translational approaches to discover novel treatment and detection methods on a molecular basis.

Mägdefessel studied Medicine at the Johannes Gutenberg University in Mainz, Germany. After receiving his doctorate and completing a clinical fellowship in cardiology, he joined the Division of Cardiovascular Medicine at Stanford University, USA. After spending 3 years as a postdoctoral researcher in Stanford, he accepted an appointment as Assistant Professor of Molecular Vascular Medicine at the Karolinska Institute in Stockholm, Sweden. In spring 2016 he was appointed Professor of Vascular Biology at TUM where he leads a research group sponsored by the German Center for Cardiovascular Research (DZHK).


    • Heisenberg Professorship of the German Research Foundation, DFG (2016)
    • Werner Risau Award of the American Heart Association, AHA, ATVB Council (2016)
    • ERC Starting Grant (2015)
    • Ragnar Söderberg Fellow in Medicine (2014)
    • Prince Daniel Research Award in Cardiovascular Sciences, Swedish Heart-Lung-Foundation (2014)

    Li DY, Busch A, Jin H, Chernogubova E, Pelisek J, Karlsson J, Sennblad B, Liu S, Lao S, Hofmann P, Bäcklund A, Eken SM, Roy J, Eriksson P, Dacken B, Ramanujam P, Dueck A, Engelhardt S, Boon RA, Eckstein HH, Spin JM, Tsao PS, Maegdefessel L: "H19 induces abdominal aortic aneurysm development and progression". Circulation. 2018.


    Eken SM, Jin H, Chernogubova E, Li Y, Simon N, Sun C, Korzunowicz G, Busch A, Bäcklund A, Österholm C, Razuvaev A, Renné T, Eckstein HH, Pelisek J, Eriksson P, González Díez M, Perisic Matic L, Schellinger IN, Raaz U, Leeper NJ, Hansson GK, Paulsson-Berne G, Hedin U, Maegdefessel L: "MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions". Circ Res. 2017; 120(4): 633-644.


    Maegdefessel L, Spin JM, Raaz U, Adam M, Azuma J, Toh RM, Deng A, Chernogubova E, Eken SM, Jin H, Roy J, Hultgren R, Caidahl K, Schrepfer S, Mc Connell MV, Hamsten A, Eriksson P, Dalman RL, Tsao PS: “miR-24 limits aortic vascular inflammation and murine abdominal aortic aneurysm development”. Nat Commun. 2014; 5: 5214.


    Maegdefessel L, Azuma J, Toh RM, Merk DR, Deng A, Raiesdana A, Leeper NJ, Raaz, U, Schoelmerich A, Mc Connell MV, Dalman RL, Spin JM, Tsao PS: “MicroRNA-21 blocks abdominal aortic aneurysm development and nicotine-augmented expansion”. Sci Transl Med. 2012; 4: 122ra22.


    Maegdefessel L, Azuma J, Toh RM, Merk DR, Deng A, Chin JT, Raiesdana A, Leeper NJ, Raaz, U, Schoelmerich A, Mc Connell MV, Dalman RL, Spin JM, Tsao PS: “Inhibition of microRNA-29b reduces abdominal aortic aneurysm development”. J Clin Invest. 2012; 122: 497-506.