Professorial Faculty
Technical University of Munich

Prof. Dr. Lars Maegdefessel

Professorship

Molecular Vascular Biology

School

TUM School of Medicine and Health

Contact Details

Business card at TUMonline

Academic Career and Research Areas

Lars Mägdefessel (b. 1977) is interested in the contribution of non-coding RNAs to vascular disease development and progression. Within vascular pathologies, his research team focuses on atherosclerotic plaque vulnerability and expanding aortic aneurysms, utilizing a variety of translational approaches to discover novel treatment and detection methods on a molecular basis.

Mägdefessel studied Medicine at the Johannes Gutenberg University in Mainz, Germany. After receiving his doctorate and completing a clinical fellowship in cardiology, he joined the Division of Cardiovascular Medicine at Stanford University, USA. After spending 3 years as a postdoctoral researcher in Stanford, he accepted an appointment as Assistant Professor of Molecular Vascular Medicine at the Karolinska Institute in Stockholm, Sweden. In spring 2016 he was appointed Professor of Vascular Biology at TUM where he leads a research group sponsored by the German Center for Cardiovascular Research (DZHK).

    Awards

    • ERC Consolidator Grant (2023)
    • Russel Ross Award der American Heart Association, AHA (2023)
    • Heisenberg Professur der Deutschen Forschungsgemeinschaft, DFG (2016)
    • Werner Risau Award der American Heart Association, AHA (2016)
    • ERC Starting Grant (2015) 

    Key Publications (all publications)

    Paloschi V, Pauli J, Winski G, Wu Z, Li Z, Botti L, Meucci S, Conti P, Rogowitz F, Glukha N, Hummel N, Busch A, Chernogubova E, Jin H, Sachs N, Eckstein HH, Dueck A, Boon RA, Bausch AR, Maegdefessel L. Utilization of an Artery-on-a-Chip to Unravel Novel Regulators and Therapeutic Targets in Vascular Diseases. Adv Healthc Mater. 2024, 13(6):e2302907.

    Abstract

    Winter H, Maegdefessel L. Targeting non-coding RNAs for novel treatment strategies in vascular diseases. Eur Heart J. 2023; 44(25):2267-2269.

    Abstract

    Winter H, Winski G, Busch A, Chernogubova E, Fasolo F, Wu Z, Bäcklund A, Khomtchouk BB, Van Booven DJ, Sachs N, Eckstein HH, Wittig I, Boon RA, Jin H, Maegdefessel L. Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression. Mol Ther. 2023, 31(6):1775-1790.

    Abstract

    Fasolo F, Jin H, Winski G, Chernogubova E, Pauli J, Winter H, Li DY, Glukha N, Bauer S, Metschl S, Wu Z, Koschinsky ML, Reilly M, Pelisek J, Kempf W, Eckstein HH, Soehnlein O, Matic L, Hedin U, Bäcklund A, Bergmark C, Paloschi V, Maegdefessel L. Long Noncoding RNA MIAT Controls Advanced Atherosclerotic Lesion Formation and Plaque Destabilization. Circulation. 2021; 144(19):1567-1583.

    Abstract

    Li DY, Busch A, Jin H, Chernogubova E, Pelisek J, Karlsson J, Sennblad B, Liu S, Lao S, Hofmann P, Bäcklund A, Eken SM, Roy J, Eriksson P, Dacken B, Ramanujam P, Dueck A, Engelhardt S, Boon RA, Eckstein HH, Spin JM, Tsao PS, Maegdefessel L. H19 induces abdominal aortic aneurysm development and progression. Circulation. 2018; 138:1551-1568.

    Abstract

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