Prof. Dr. Henrike Niederholtmeyer
Academic Career and Research Areas
Prof. Niederholtmeyer (1984*) conducts research in the field of cell-free synthetic biology. This approach uses cell-free expression systems to rapidly characterize new genetic constructs and proteins. Another goal is to build life-like systems from simple (bio)chemical components. Here, Niederholtmeyer’s team studies the effects of spatial order on complex biochemical systems, and aims to engineer specialized compartments for practical applications.
Prof. Niederholtmeyer studied biotechnology at the University of Münster and the Harvard Medical School. She completed her PhD at the École Polytechnique Fédérale de Lausanne and conducted postdoctoral research at the University of California, San Diego. From 2020 to 2022, she led the Emmy Noether Research Group "Cell-Free Synthetic Biology" at the Max Planck Institute for Terrestrial Microbiology in Marburg. She was appointed as Tenure Track Assistant Professor for Synthetic Biology at TUM in 2022.
Awards
- ERC Starting Grant "SYNSEMBL" (2022)
- Emmy Noether research group, German Research Foundation (2020)
- Postdoc fellowships, Swiss National Science Foundation (2015-2019)
Key Publications (all publications)
Böhm CV, Inckemann R, Burgis M, Baumann J, Brinkmann CK, Lipińska KE, Gilles S, Freudigmann J, Seiler V, Clark LG, Jewett MC, Voll LM, Niederholtmeyer H: "Chloroplast cell-free systems from different plant species as a rapid prototyping platform". ACS Synthetic Biology. 2024; 13: 2412-2424.
AbstractLehr FX, Pavletic B, Glatter T, Heimerl T, Moeller R, Niederholtmeyer H: "Enhanced assembly of bacteriophage T7 produced in cell-free reactions under simulated microgravity". npj Microgravity. 2024; 10: 30.
AbstractBanlaki I, Lehr FX, Niederholtmeyer H: "Microfluidic production of porous polymer cell-mimics capable of gene expression". In: Cell-Free Gene Expression. Methods in Molecular Biology. Karim AS, Jewett MC. New York, NY: Humana, 2022: vol 2433.
AbstractBhattacharya A, Niederholtmeyer H, Podolsky KA, Bhattacharya R, Song JJ, Brea RJ, Tsai CH, Sinha SK, Devaraj NK: "Lipid Sponge Droplets as Programmable Synthetic Organelles". Proceedings of the National Academy of Sciences USA. 2020; 117: 18206-18215.
AbstractNiederholtmeyer H, Chaggan C, Devaraj NK: "Communication and quorum sensing in non-living mimics of eukaryotic cells". Nature Communications. 2018; 9: 5027.
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