Apl. Prof. Dr. Gerhard Rammes
Academic Career and Research Areas
Prof. Rammes' (*1965) field of research is the area of anaesthesia, neuroprotection and neurodegeneration (e.g. Alzheimer’s disease (AD)) and neuronal mechanisms related to learning and memory. Focusing on the ß-amyloid-derived pathophysiology of AD, we are interested in the neurotoxic effects, the interaction of anaesthetics and neurosteroids and the pharmacological prevention by receptor modulators or aggregation inhibitors.
Prof. Rammes studied biology at the Friedrich-Alexander-Universität Erlangen-Nuremberg and finished his PhD 1996 in Birmingham. From 1997 - 2002 he held a postdoc position at the Max-Planck-Institute for Psychiatry in Munich and habilitated 2002 in the fields of neuropharmacology. From 2003-2004 he was employed at the pharmaceutical company Cephalon. Since 2004 he is a group leader of the research group Experimental Neuropharmacology at TUM. In 2008 Prof. Rammes was appointed to the professorship (apl) at TUM.
Key Publications
Rammes G, Parsons CG: “The Abeta aggregation modulator MRZ-99030 prevents and even reverses synaptotoxic effects of Abeta1-42 on LTP even following serial dilution to a 500:1 stoichiometric excess of Abeta1-42, suggesting a beneficial prion-like seeding mechanism”. Neuropharmacology. 2020; 108267.
AbstractMattusch C, Kratzer S, Buerge M, Kreuzer M, Engel T, Kopp C, Biel M, Hammelmann V, Ying SW, Goldstein PA, Kochs E, Haseneder R, Rammes G: “Impact of Hyperpolarization-activated, Cyclic Nucleotide-gated Cation Channel Type 2 for the Xenon-mediated Anesthetic Effect: Evidence from In Vitro and In Vivo Experiments”. Anesthesiology. 2015; 122(5):1047-59
AbstractRupprecht R, Rammes G, Eser D, Baghai TC, Schule C, Nothdurfter C, Troxler T, Gentsch C, Kalkman HO, Chaperon F, Uzunov V, McAllister KH, Bertaina-Anglade V, La Rochelle CD, Tuerck D, Floesser A, Kiese B, Schumacher M, Landgraf R, Holsboer F, Kucher K: “Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects”. Science. 2009; 325:490-3.
AbstractRammes G, Sillaber I, Zimmermann S, Mahal B, Zieglgansberger W, Wurst W, Holsboer F, Spanagel R: “Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors”. Science. 2002; 296:931-933.
AbstractMarsicano G, Wotjak CT, Azad SC, Bisogno T, Rammes G, Cascio MG, Hermann H, Tang J, Hofmann C, Zieglgansberger W, Di Marzo V, Lutz B: “The endogenous cannabinoid system controls extinction of aversive memories”. Nature. 2002; 418:530-534.
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