Prof. Dr. Michael Sattler
Academic Career and Research Areas
The research of Prof. Sattler (b. 1965) focuses on the development and application of biomolecular nuclear magnetic resonance (NMR) spectroscopy and integrative strcutral biology. The aim is to describe the structure, dynamics and molecular interactions of biological macromolecules (proteins, RNAs with each other and with small molecules and drug-like compounds). This should provide a better understanding of the basic molecular mechanisms of fundamental biological processes and disease pathways.
After studying chemistry and completing his doctorate (1995) at J.W. Goethe University in Frankfurt, Prof. Sattler went to Chicago to do research under Dr. Stephen W. Fesik (Abbott Laboratories). In 1997, he became group leader at the European Laboratory for Molecular Biology (EMBL) in Heidelberg. Since 2007, he has been full professor at TUM’s chemistry department in Garching. Prof. Sattler is also Director of the Institute of Structural Biology at Helmholtz Zentrum München and Director of the Bavarian NMR Center.
Awards
- ERC Synergy Grant UNLEASH (2023)
- The Stifterverband Science Award – Erwin Schrödinger Prize (2020)
- Elected Member of the Leopoldina, German National Academy of Sciences (2017)
- Elected Member of the European Molecular Biology Organization (EMBO) (2012)
Key Publications (all publications)
Jones AN, Graß C, Meininger I, Geerlof A, Klostermann M, Zarnack K, Krappmann D, Sattler M. “Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of MALT1”. Sci Adv. 2022;8(31):1-15.
AbstractHennig J, Militti C, Popowicz GM, Wang I, Sonntag M, Geerlof A, Gabel F, Gebauer F, Sattler M: "Structural basis for the assembly of the Sxl–UNR translation regulatory complex". Nature. 2014; 515: 287-90.
AbstractMackereth CD, Madl T, Bonnal S, Simon B, Zanier K, Gasch A, Rybin V, Valcarcel J, Sattler M: “Multi-domain conformational selection underlies pre-mRNA splicing regulation by U2AF”. Nature. 2011; 475(7356): 408-411.
AbstractLingel A, Simon B, Izaurralde E, and Sattler M: “Structure and nucleic-acid binding of the Drosophila Argonaute 2 PAZ domain”. Nature. 2003; 426: 465-9.
AbstractLiu Z, Luyten I, Bottomley MJ, Messias AC, Houngninou-Molango S, Sprangers R, Zanier K, Krämer A, Sattler M: “Structural basis for recognition of the intron branch site RNA by splicing factor 1”. Science. 2001; 294: 1098-102.
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