Prof. Dr. Matthew Tredwell
Academic Career and Research Areas
Professor Tredwell studied Chemistry at the University Oxford, where he earned his doctorate in organic chemistry in 2007 before completing postdoctoral research at both the University of Cambridge and the University of Oxford. He established his independent research group at the Max-Planck-Institute für Kohlenforschung in 2015. In 2019, Professor Tredwell joined Cardiff University, appointed jointly between the Schools of Chemistry and Medicine. Since 2026, he is Professor of Pharmaceutical Radiochemistry at TUM.
Prof. Tredwell’s (*1981) research spans the fields of chemical synthesis, radiochemistry, and the development of targeted radiopharmaceuticals for imaging and therapy. He has developed innovative methods and reagents for the 18F-fluorination of small molecules and biomolecules, enabling the efficient production of positron emission tomography (PET) radiotracers, particularly for neuroimaging. These methods have been widely adopted for both research and clinical studies.
Key Publications
M. Qin et al: “The synthesis of [18F]SynVesT-1 and [18F]SynVesT-2 from enantioenriched boronic esters”. Chem. Comm. 2025; 61: 17689-17692.
AbstractP. Mishra et al: “Radiochemical synthesis of alkyl geminal 18F-difluoroalkyl motifs mediated by silver (I) oxide”. Org. Lett. 2025; 27: 1724-1728.
AbstractJ. Ford et al: “Expedient access to 18F-fluoroheteroarenes via deaminative radiofluorination of aniline-derived pyridinium salts”. Angew. Chem. Int. Ed. 2024; 63: e202404945.
AbstractJ. Sap et al: “[18F]Difluorocarbene for positron emission tomography”. Nature. 2022; 606: 102-108.
AbstractGendron T et al: “Multi-patient dose synthesis of [18F]Flumazenil via a copper-mediated 18F-fluorination”. EJNMMI Radiopharm. Chem. 2022; 7: 5.
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