Prof. Dr. Nina Henriette Uhlenhaut

Professorship

Metabolic Programming​​​​​​​

Contact Details

Business card at TUMonline​​​​​​​

Academic Career and Research Areas

Prof. Uhlenhaut's (*1977) research focuses on investigating gene regulatory mechanisms that mediate hormone responses. Latest genome-wide techniques are combined with preclinical models to find new therapeutic approaches for metabolic or inflammatory diseases (e.g. diabetes, asthma). 

Prof. Uhlenhaut studied at the Technical University of Braunschweig and at Georgia Tech in Atlanta. She received her doctorate from EMBL in Heidelberg and, after postdoctoral research at the Salk Institute in San Diego and the MDC in Berlin, came to Helmholtz Zentrum München as group leader. She was also professor at the Gene Center of the LMU. In 2019, Prof. Uhlenhaut was appointed professor of 'Metabolic Programming' at the TUM.

    Awards

    • Heinz Maier-Leibnitz Prize of the German Research Foundation DFG (2019)
    • Friedmund Neumann Prize of the Schering Stiftung (2015)
    • ERC Starting Grant SILENCE (2014)
    • DFG Emmy Noether Programm (2013)
    • EMBO Long Term Fellowship (2010)

    Key Publications

    Quagliarini F, Mir AA, Balazs K, Wierer M, Dyar KA, Jouffe C, Makris K, Hawe J, Heinig M, Filipp FV, Barish GD, Uhlenhaut NH: “Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet”. Molecular Cell. 2019; 76 (4): 531-545.

    Abstract

    Hemmer MC et al.: “E47 modulates hepatic glucocorticoid action”. Nature Communications. 2019; 10 (1): 306.

    Abstract

    Dyar KA et al.: “Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock”. PLOS Biology. 2018; 16 (8): e2005886.

    Abstract

    Lim HW, Uhlenhaut NH et al.: “Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo”. Genome Research. 2015; 25(6): 836-844.

    Abstract

    Uhlenhaut NH et al.: “Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes”. Molecular Cell. 2013; 49 (1): 158-171.

    Abstract