Prof. Dr. Nina Henriette Uhlenhaut
Academic Career and Research Areas
Prof. Uhlenhaut's (*1977) research focuses on investigating gene regulatory mechanisms that mediate hormone responses. Latest genome-wide techniques are combined with preclinical models to find new therapeutic approaches for metabolic or inflammatory diseases (e.g. diabetes, asthma).
Prof. Uhlenhaut studied at the Technical University of Braunschweig and at Georgia Tech in Atlanta. She received her doctorate from EMBL in Heidelberg and, after postdoctoral research at the Salk Institute in San Diego and the MDC in Berlin, came to Helmholtz Zentrum München as group leader. She was also professor at the Gene Center of the LMU. In 2019, Prof. Uhlenhaut was appointed professor of 'Metabolic Programming' at the TUM.
Awards
- EJE-Preis (2023)
- ERC Consolidator Grant GRACE (2023)
- Heinz Maier-Leibnitz-Preis der DFG (2019)
- Friedmund Neumann-Preis der Scheringstiftung (2015)
- ERC Starting Grant SILENCE (2014)
Key Publications (all publications)
Makris K, Fonda V, Ramadhani FF, Fadel L, Davezac M, Payet B, Deligiannis IK, Zhang L, Horn T, Heimerl L, Jouffe C, Heddes M, Martinez‑Jimenez CP, Quagliarini F, Uhlenhaut NH: „Hepatic metabolic reprogramming in male mice during short-term caloric restriction involves enhanced glucocorticoid rhythms“. Nature Communications. 2025; 16(1):11106.
AbstractGreulich F, Wierer M, Mechtidou A, Gonzalez‑Garcia O, Uhlenhaut N.H.: „The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers“. Cell Reports. 2021; 34(6):108742.
AbstractEscoter‑Torres L, Greulich F, Quagliarini F, Wierer M, Uhlenhaut N.H.: „Anti-inflammatory functions of the glucocorticoid receptor require DNA binding“. Nucleic Acids Research. 2020; 48(15): 8393–8407.
AbstractQuagliarini F, Mir AA, Balazs K, Wierer M, Dyar KA, Jouffe C, Makris K, Hawe J, Heinig M, Filipp FV, Barish GD, Uhlenhaut NH: „Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet“. Molecular Cell. 2019; 76(4): 531–545.e5.
AbstractHemmer MC, Wierer M, Schachtrup K, Downes M, Hübner N, Evans RM, Uhlenhaut NH: „E47 modulates hepatic glucocorticoid action.“ Nature Communications. 2019; 10(1):306.
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