
Prof. Dr. Alexander Bartelt
Academic Career and Research Areas
Alexander Bartelt (*1982) deals with the molecular biology of metabolism and how it gets out of joint in obesity, fatty liver, diabetes and cardiovascular diseases. He has gained important insights into the molecular functioning of fat metabolism, fat cells and their interaction with the immune system. Through his work on nutrition, energy metabolism and thermogenesis, he is helping to shed light on the question of how weight gain and weight loss are regulated at the cellular level. His work places metabolic adaptation to stress factors at the center of the pathogenesis of complex cardiometabolic diseases.
After studying biochemistry and molecular biology at the University of Hamburg, he began his scientific career at the University Medical Center Hamburg-Eppendorf, where he received his doctorate with distinction in 2010 on molecular mechanisms of lipid metabolism.He continued his research on brown adipose tissue at Harvard University, Boston, USA, in 2013 and then returned to Germany as Professor of Cardiovascular Metabolism at Ludwig Maximilian University of Munich in 2019.Since 2024, he has headed the Chair of Translational Nutritional Medicine as Else Kröner Fresenius Professor at the TUM Weihenstephan Campus.Prof. Bartelt is also a research group leader at the Helmholtz Diabetes Center and a member of the German Center for Diabetes Research (DZD) and the German Center for Cardiovascular Diseases (DZHK). He has received several national and international awards for his research.
Awards
- ERC Starting Grant (2019)
- Friedmund Neumann Preis der Schering Stiftung (2018)
- ISSFAL Early Career Award (2014)
- Forschungstipendium der DFG (2013)
- Karl-Lohmann-Preis der GBM (2011)
Key Publications (all publications)
Ofoghi A, Kotschi S, Lemmer IL, Haas DT, Willemsen N, Bayer B, Jung AS, Möller S, Haberecht-Müller S, Krüger E, Krahmer N, Bartelt A. Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis. Cell Death Differ. 2024 Oct 9. doi: 10.1038/s41418-024-01398-z. Online ahead of print. PMID: 39384955.
AbstractBrunetta HS, Jung AS, Valdivieso-Rivera F, de Campos Zani SC, Guerra J, Furino VO, Francisco A, Berçot M, Moraes-Vieira PM, Keipert S, Jastroch M, Martinez LO, Sponton CH, Castilho RF, Mori MA, Bartelt A. IF1 is a cold-regulated switch of ATP synthase hydrolytic activity to support thermogenesis in brown fat. EMBO J. 2024 Nov;43(21):4870-4891. doi: 10.1038/s44318-024-00215-0. Epub 2024 Sep 16. PMID: 39284909.
AbstractGiroud M, Kotschi S, Kwon Y, Le Thuc O, Hoffmann A, Gil-Lozano M, Karbiener M, Higareda-Almaraz JC, Khani S, Tews D, Fischer-Posovszky P, Sun W, Dong H, Ghosh A, Wolfrum C, Wabitsch M, Virtanen KA, Blüher M, Nielsen S, Zeigerer A, García-Cáceres C, Scheideler M, Herzig S, Bartelt A. The obesity-linked human lncRNA AATBC stimulates mitochondrial function in adipocytes. EMBO Rep. 2023 Oct 9;24(10):e57600. doi: 10.15252/embr.202357600. Epub 2023 Sep 6. PMID: 37671834.
AbstractWillemsen N, Arigoni I, Studencka-Turski M, Krüger E, Bartelt A. Proteasome dysfunction disrupts adipogenesis and induces inflammation via ATF3. Mol Metab. 2022 Aug;62:101518. doi: 10.1016/j.molmet.2022.101518. Epub 2022 May 28. PMID: 35636710.
AbstractBartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, Tseng YH, Inouye KE, Arruda AP, Hotamisligil GS. Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity. Nat Med. 2018 Mar;24(3):292-303. doi: 10.1038/nm.4481. Epub 2018 Feb 5. PMID: 29400713.
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