Prof. Dr. Angela Casini
Academic Career and Research Areas
The research of Prof. Casini (*1973) spans the areas of inorganic, bioinorganic and medicinal chemistry. The study of the role of metal ions in biological systems and of the mechanisms of action of metal-based drugs are active topics of her research program. The design of the metal compounds targeted to selected biomolecules (proteins and nucleic acids) is optimized to exploit metal-templated reactions for bioorthogonal transformations in aqueous environment, eventually enabling catalysis in living systems. Furthermore, novel applications for metal compounds and supramolecular coordination complexes are explored in various domains of chemical biology, drug delivery and medicine.
Professor Casini completed her PhD in Chemistry at the University of Florence (Italy) in 2004, and, afterwards, moved to EPFL (Switzerland) as senior scientist funded by the Swiss National Science Foundation. Between 2011-2015 she has been assistant professor at the University of Groningen (The Netherlands), holding a Rosalind Franklin Fellowship. Between 2015-2019, she was also professor at Cardiff University (UK), before taking up her current position as Chair of Medicinal and Bioinorganic Chemistry at TUM in 2019.
Awards
- ACS Inorganic Lectureship award (2019)
- Burghausen Diamond of Chemistry Award (Chemiediamant) (2018)
- Hans Fischer Senior Fellowship, IAS-TUM (2016)
- European Medal for Biological Inorganic Chemistry (2012)
- Rosalind Franklin Fellowship, University of Groningen, The Netherlands (2011)
Key Publications
Spreckelmeyer S et al.: N-Heterocyclic Carbenes as Ligands to 198Au(I) Radiolabeled Compounds: a New Platform for Radiopharmaceutical Design”. J. Med. Chem. 2025; 68: 17516-17526.
AbstractMoreno-Alcántar G et al.: „Assembling a new generation of radiopharmaceuticals with supramolecular theranostics”. Nat. Rev. Chemistry. 2024; 8: 893-914.
AbstractDeiser S et al.: „(SiFA)SeFe: A Hydrophilic Silicon-Based Fluoride Acceptor Enabling Versatile Peptidic Radiohybrid Tracers”. J. Med. Chem. 2024; 67:14077-14094.
AbstractLovison D et al.: „Beyond Metal-Arenes: Monocarbonyl Ruthenium(II) Catalysts for Transfer Hydrogenation Reactions in Water and in Cells”. ACS Catalysis. 2023; 13: 10798-10823.
AbstractSkos L et al.: „Gold-templated covalent targeting of the CysSec-dyad of thioredoxin reductase 1 in cancer cells”. Cell Reports Physical Science. 2024; 5: 102072.
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