Dr. Nicolas Battich

Helmholtz Pioneer Campus (HPC) Principal Investigator

Quantitative Cell Biology

Department

Chair of Mathematical Modeling of Biological Systems (Prof. Theis)

TUM School of Life Sciences

 

Academic Career and Research Areas

Nicolas Battich is interested in the strategies that cells use to control gene expression levels and variability during differentiation. He researches the links between the dynamic nuclear structures and transcriptional changes in singe cells. As part of his work, he develops cutting-edge quantitative methods for single-cell genomics and combine them with cellular phenotyping using high-content confocal microscopy. He also builds quantitative predictive models and use state-of-the-art machine-learning to gain insights into the process of embryonic stem cell differentiation.

Nicolas Battich began his scientific career in Scotland, where in 2010 he obtained a first-class degree in Molecular and Cellular Biology from the University of Glasgow. He carried out his Ph.D. in Systems Biology at the University of Zurich. Nicolas has been awarded postdoctoral fellowships from the Swiss National Science Foundation and the Human Frontier Science Program to conduct research at the Hubrecht Institute in the Netherlands. He is a group leader at the Helmholtz Pioneer Campus in Munich since August 2022, where he investigates the systems biology of stem cell differentiation.

    Awards

    • Human Frontier Science Program Postdoctoral Fellowship (2017)
    • SNSF Early Mobility Postdoctoral Fellowship (2017)
    • Annual Prize of the Faculty of Science for best Doctoral Thesis, University of Zurich, Switzerland (2016)
    • Class Prize Molecular and Cellular Biology, University of Glasgow, UK (2010)
    • Sainsbury Studentship of the Gatsby Foundation, UK (2009)

    Battich N, Beumer J, de Barbanson B, Krenning L, Chloé B, Tanenbaum M, Clevers H, van Oudenaarden A: “Sequencing metabolically labeled transcripts in single cells reveals mRNA turnover strategies”. Science. 2020; 367 (6482): 1151-1156 

    Abstract

    Berchtold D, Battich N, Pelkmans L: “A systems-level study reveals regulators of membrane-less organelles in human cells”. Molecular Cell. 2018; 72 (6): 1035-1049.e5

    Abstract

    Stoeger T, Battich N, Pelkmans L: “Passive Noise Filtering by Cellular Compartmentalization”. Cell. 2016; 164 (6): 1151-1161

    Abstract

    Battich N, Stoeger T, Pelkmans L: “Control of transcript variability in single mammalian cells”. Cell. 2015; 163 (7): 1596-1610

    Abstract

    Battich N, Stoeger T, Pelkmans L: “Image-based transcriptomics in thousands of single human cells at single-molecule resolution”. Nature Methods. 2013; 10 (11): 1127-1133

    Abstract