Dr. Melanie Köhler

Leibniz Junior Research Group

Mouthfeel – How texture makes flavor
Chair of Nutritional Systems Biology

Academic Career and Research Areas

Dr. Köhler obtained her PhD in biophysics at the Johannes Kepler University Linz, Austria in the group of Prof. Peter Hinterdorfer (Dept. of applied experimental biophysics). After that, at the end of 2016, she moved to the UCLouvain in Belgium, where she worked as postdoctoral researcher in the nanobiophysics lab under the lead of Prof. David Alsteens. There, she explored the molecular mechanisms behind virus binding to cell surface receptors. In 2022, she has received funding from the Leibniz association to establish as an independent junior research group at the LSB.

Dr. Melanie Köhler (b. 1988) is the head of the Junior Research Group Mechanoreceptors at the Leibniz Institute for Food Systems Biology at the Technical University of Munich (LSB). Her interdisciplinary research group seeks to combine experimental biophysics (mostly atomic force microscopy) with methods from food chemistry and biology to set up a new experimental research platform for food-related research. Her current work aims at deciphering the molecular basis underlying oral texture perception, i.e. mouthfeel, mediated by mechanoreceptors. 

    Awards

    • Winner of Nestlé Award for Excellence in Flavor Science at 13th Wartburg Symposium on Flavor Chemistry and Biology (2023)
    • Leibniz Junior Research Group grant funded by the Leibniz association and Leibniz LSB within the scope of the Leibniz competition (2022)
    • Postdoctoral fellowship funded by Fonds de la Recherche Scientifique (FNRS) Belgium (2020)
    • Erwin Schrödinger Abroad Fellowship funded by Austrian Science Fund (FWF), Austria (2017)
    • Scholarship grants to support unfinished dissertations (JKU Linz, Austria) (2013-2015)

    Dumitru A.* & Koehler, M.* "Recent advances in the application of atomic force microscopy to structural biology". Journal of structural biology. 2023; 215 (2), 107963   *corresponding author

    Abstract

    Simpson, J. D., Marcon, C., Ray, A., Dorrazehi, M. G., Dos Santos Natividade, R., Durlet, K., Koehler, M.* & Alsteens, D.* Single-Molecule Analysis of SARS-CoV-2 Binding to C-Type Lectin Receptors." Nano Letters. 2023; 23 (4), 1496–1504 *corresponding author

    Abstract

    Koehler M. et al., Biophysical investigations using atomic force microscopy can elucidate the link between mouthfeel and flavour perception; Nature food (in press)

    Abstract

    Koehler, M., Petitjean, S., Yang, J., Aravamudhan, P., Somoulay, X., Lo Giudice, C., Poncin, M., Dumitru, A. C., Dermody, T. S. & Alsteens D. "Reovirus directly engages integrin to recruit clathrin for entry into host cells. Nature communications. 2021; 12, 2149

    Abstract

    Koehler, M., Lo Giudice, C., Vogl, P., Ebner, A., Hinterdorfer, P., Gruber, H. J., & Alsteens, D. "Control of ligand-binding specificity using photocleavable linkers in AFM force spectroscopy" Nano letters. 2020; 20(5), 4038-4042

    Abstract