Dr. Celia Martinez Jimenez

Helmholtz Pioneer Campus Principal Investigator (HPC)

Molecular Ageing

Department

Professorship of Molecular Metabolic Control (Prof. Herzig)

Department of Medicine

Academic Career and Research Areas

Martinez-Jimenez's Lab aims to compare "molecular age" (predetermined by molecular characteristics such as DNA methylation, chromatin accessibility and cell-to-cell transcriptional variability) with conventional "chronological age" (defined by the age of an individual in units of time, years). These molecular characteristics will be used to decipher the influence of cellular variability on tissue function during ageing and in chronic diseases.

Dr. Martinez-Jimenez completed her Master of Science in Biology in 2000 and in Biochemistry in 2003 at the University of Valencia (Spain). She received a scholarship from the Spanish government for her doctoral thesis and funding for two stays abroad. The result was a European (2006) and a national award from the University of Valencia (2207) for her doctoral thesis. She then received a Marie Curie Programme (ITN) grant and a long-term FEBS grant. In 2012, Dr. Martinez-Jimenez moved to the private sector and improved her strategic thinking and project management. In 2015, Dr. Martinez-Jimenez returns to science with a Janet Thornton Fellowship to the Wellcome Trust Sanger Institute and Cancer Research UK Cambridge Institute. In 2018 she founded her own independent research group at the Helmholtz Pioneer Campus.

    Awards

    • Inaugural Janet Thornton Fellow at Wellcome Trust Sanger Institute and Cancer Research UK Cambridge Institute (2015).
    • Postdoctoral Long-Term FEBS fellowship by Federation of European Biochemical Societies (FEBS) at Biomedical Research Centre Príncipe Felipe (2010)
    • National PhD Award by the University of Valencia (2007)
    • Marie Curie postdoctoral fellowship at B.S.R.C. Alexander Fleming and FORTH Institute (2006)

    Key Publications

    Ernst C, Eling N, Martinez-Jimenez CP, Marioni JC.: „Staged developmental mapping and X chromosome transcriptional dy-namics during mouse spermatogenesis“. Odom DT.  Nat Commun. 2019 Mar 19

    Abstract

    Martinez-Jimenez CP, Eling N, Chen HC, Vallejos CA, Kolodziejczyk AA, Connor F, Stojic L, Rayner TF, Stubbington MJT, Teichmann SA, de la Roche M, Marioni JC.: „Aging increases cell-to-cell transcriptional variability upon immune stimulation“. Odom DT. Science. 2017 Mar 31

    Abstract

    Martinez-Jimenez CP.: „The mechanisms shaping the single-cell transcriptional landscape“. Odom DT. Curr Opin Genet Dev. 2016 Apr;37:27-35.

    Abstract

    Schmidt D, Wilson MD, Ballester B, Schwalie PC, Brown GD, Marshall A, Kutter C, Watt S, Martinez-Jimenez CP, Mackay S, Talianidis I, Flicek P.: „Five-vertebrate ChIP-seq reveals the evolutionary dynamics of transcription factor binding“.  Odom DT. Science. 2010 May 21

    Abstract

    Martinez-Jimenez CP, Kyrmizi I, Cardot P, Gonzalez FJ, Talianidis I.: “Hepatocyte nuclear factor 4alpha coordinates a transcription factor network regulating hepatic fatty acid metabolism“ . Mol Cell Biol. 2010 Feb;30(3)

    Abstract

    Martínez-Jiménez CP, Gómez-Lechón MJ, Castell JV, Jover R.: “Transcriptional regulation of the human hepatic CYP3A4: identification of a new distal enhancer region responsive to CCAAT/enhancer-binding protein beta isoforms (liver activating protein and liver inhibitory protein)“. Mol Pharmacol. 2005 Jun;67(6)

    Abstract